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Agtr1a angiotensin II receptor, type 1a [ Rattus norvegicus (Norway rat) ]

Gene ID: 24180, updated on 17-May-2016
Official Symbol
Agtr1aprovided by RGD
Official Full Name
angiotensin II receptor, type 1aprovided by RGD
Primary source
RGD:2070
See related
Ensembl:ENSRNOG00000018346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
AT1; AT1A; AT1R; Agtr1
Summary
receptor for and mediator of vascular remodeling effects of angiotensin II [RGD, Feb 2006]
Location:
17q12
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (35906084..35958132, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (37217810..37270540, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene glycogenin-1-like Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 Neighboring gene similar to vitamin K epoxide reductase complex, subunit 1-like 1 isoform 2 Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene non-POU domain-containing octamer-binding protein-like Neighboring gene uncharacterized LOC103694081 Neighboring gene E2F transcription factor 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
G-protein alpha-subunit binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin type I receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin type I receptor activity ISO
Inferred from Sequence Orthology
more info
 
angiotensin type II receptor activity IEA
Inferred from Electronic Annotation
more info
 
angiotensin type II receptor activity ISO
Inferred from Sequence Orthology
more info
 
bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
activation of Janus kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
brain renin-angiotensin system IEA
Inferred from Electronic Annotation
more info
 
brain renin-angiotensin system ISO
Inferred from Sequence Orthology
more info
 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
NOT negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating angiotensin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor recycling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
regulation of pH IDA
Inferred from Direct Assay
more info
PubMed 
regulation of renal output by angiotensin IEA
Inferred from Electronic Annotation
more info
 
regulation of renal output by angiotensin ISO
Inferred from Sequence Orthology
more info
 
regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
renin secretion into blood stream IEA
Inferred from Electronic Annotation
more info
 
renin secretion into blood stream ISO
Inferred from Sequence Orthology
more info
 
renin-angiotensin regulation of aldosterone production IMP
Inferred from Mutant Phenotype
more info
PubMed 
renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt stress IEP
Inferred from Expression Pattern
more info
PubMed 
vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
organelle outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
vesicle lumen IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
type-1A angiotensin II receptor
Names
angiotensin II type-1A receptor
angiotensin receptor 1a
vascular type-1 angiotensin II receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030985.4NP_112247.2  type-1A angiotensin II receptor

    See identical proteins and their annotated locations for NP_112247.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078810
    UniProtKB/Swiss-Prot
    P25095
    Related
    ENSRNOP00000034687, ENSRNOT00000038532
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37156
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    35906084..35958132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771594.1XP_008769816.1  

    See identical proteins and their annotated locations for XP_008769816.1

    UniProtKB/Swiss-Prot
    P25095
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37156
    7tm_4; Olfactory receptor
  2. XM_008771593.1XP_008769815.1  

    Conserved Domains (2) summary
    pfam00001
    Location:80331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:66185
    7tm_4; Olfactory receptor
  3. XM_006253882.2XP_006253944.1  

    See identical proteins and their annotated locations for XP_006253944.1

    UniProtKB/Swiss-Prot
    P25095
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37156
    7tm_4; Olfactory receptor

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    33705975..33757157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)