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Adh1 alcohol dehydrogenase 1 (class I) [ Rattus norvegicus (Norway rat) ]

Gene ID: 24172, updated on 8-May-2016
Official Symbol
Adh1provided by RGD
Official Full Name
alcohol dehydrogenase 1 (class I)provided by RGD
Primary source
RGD:2044
See related
Ensembl:ENSRNOG00000012436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Adh; Adh1a; Adh1c
Summary
alpha subunit of class I alcohol dehydrogenase; metabolizes a wide variety of substrates including ethanol, hydroxysteroids and lipid peroxidation products [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
2q44
Exon count:
9
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243550657..243562243)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (262090818..262102977)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Neighboring gene uncharacterized LOC102556058 Neighboring gene uncharacterized LOC102556144 Neighboring gene alcohol dehydrogenase 6A (class V)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD binding IDA
Inferred from Direct Assay
more info
PubMed 
alcohol dehydrogenase (NAD) activity IDA
Inferred from Direct Assay
more info
PubMed 
alcohol dehydrogenase (NAD) activity ISO
Inferred from Sequence Orthology
more info
 
alcohol dehydrogenase (NAD) activity TAS
Traceable Author Statement
more info
PubMed 
alcohol dehydrogenase activity, zinc-dependent ISO
Inferred from Sequence Orthology
more info
 
drug binding IPI
Inferred from Physical Interaction
more info
PubMed 
ethanol binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetaldehyde biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
 
ethanol catabolic process ISO
Inferred from Sequence Orthology
more info
 
ethanol oxidation IDA
Inferred from Direct Assay
more info
PubMed 
ethanol oxidation ISO
Inferred from Sequence Orthology
more info
 
organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
response to testosterone ISO
Inferred from Sequence Orthology
more info
 
retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
alcohol dehydrogenase 1
Names
alcohol dehydrogenase (class I), alpha polypeptide
alcohol dehydrogenase 1, complex
alcohol dehydrogenase 1C (class I), gamma polypeptide
alcohol dehydrogenase A subunit
NP_062159.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019286.4NP_062159.3  alcohol dehydrogenase 1

    See identical proteins and their annotated locations for NP_062159.3

    Status: VALIDATED

    Source sequence(s)
    AC118967, BC062403, FQ218571
    UniProtKB/Swiss-Prot
    P06757
    Related
    ENSRNOP00000072955, ENSRNOT00000083682
    Conserved Domains (2) summary
    cd08299
    Location:3376
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
    COG1062
    Location:8376
    FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    243550657..243562243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    218954200..218965645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)