Format

Send to:

Choose Destination

Xrn2 5'-3' exoribonuclease 2 [ Mus musculus (house mouse) ]

Gene ID: 24128, updated on 28-May-2016
Official Symbol
Xrn2provided by MGI
Official Full Name
5'-3' exoribonuclease 2provided by MGI
Primary source
MGI:MGI:894687
See related
Ensembl:ENSMUSG00000027433 Vega:OTTMUSG00000015692
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
2; 2 H1
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (147012631..147078002)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (146838796..146903736)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene kizuna centrosomal protein Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene Mki67 (FHA domain) interacting nucleolar phosphoprotein pseudogene Neighboring gene predicted gene, 34889 Neighboring gene NK2 homeobox 4

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5'-exoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
5'-3' exoribonuclease activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription termination site sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA catabolic process, exonucleolytic ISO
Inferred from Sequence Orthology
more info
 
DNA recombination NAS
Non-traceable Author Statement
more info
PubMed 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
DNA-templated transcription, termination IEA
Inferred from Electronic Annotation
more info
 
RNA metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
microtubule-based process TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
aggresome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
5'-3' exoribonuclease 2
Names
protein Dhm1
NP_036047.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011917.2NP_036047.2  5'-3' exoribonuclease 2

    See identical proteins and their annotated locations for NP_036047.2

    Status: PROVISIONAL

    Source sequence(s)
    BC054743
    Consensus CDS
    CCDS38258.1
    UniProtKB/Swiss-Prot
    Q9DBR1
    Related
    ENSMUSP00000028921, OTTMUSP00000016705, ENSMUST00000028921, OTTMUST00000037296
    Conserved Domains (2) summary
    COG5049
    Location:1787
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam03159
    Location:2255
    XRN_N; XRN 5'-3' exonuclease N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    147012631..147078002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239519.1XP_011237821.1  

    Conserved Domains (2) summary
    COG5049
    Location:1739
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam03159
    Location:2255
    XRN_N; XRN 5'-3' exonuclease N-terminus
  2. XM_006499450.2XP_006499513.1  

    Conserved Domains (2) summary
    COG5049
    Location:1621
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]
    pfam03159
    Location:189
    XRN_N; XRN 5'-3' exonuclease N-terminus
  3. XM_006499451.1XP_006499514.1  

    Conserved Domains (1) summary
    COG5049
    Location:68363
    XRN1; 5'-3' exonuclease [Replication, recombination and repair]

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    148268335..148333354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)