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Klhl12 kelch-like 12 [ Mus musculus (house mouse) ]

Gene ID: 240756, updated on 28-May-2016
Official Symbol
Klhl12provided by MGI
Official Full Name
kelch-like 12provided by MGI
Primary source
MGI:MGI:2385619
See related
Ensembl:ENSMUSG00000026455 Vega:OTTMUSG00000021463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3ip1
Orthologs
Location:
1; 1 E4
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (134455495..134490875)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136352132..136387450)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 1 Neighboring gene adiponectin receptor 1 Neighboring gene RAB interacting factor Neighboring gene predicted gene 29376

Markers

Homology

Clone Names

  • MGC7076

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
 
COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
 
ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
kelch-like protein 12
Names
CUL3-interacting protein 1
kelch-like protein C3IP1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311136.1NP_001298065.1  kelch-like protein 12 isoform 1

    See identical proteins and their annotated locations for NP_001298065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK034170, CD364043
    Consensus CDS
    CCDS78687.1
    UniProtKB/Swiss-Prot
    Q8BZM0
    Conserved Domains (5) summary
    smart00612
    Location:474520
    Kelch; Kelch domain
    PHA03098
    Location:46550
    PHA03098; kelch-like protein; Provisional
    pfam00651
    Location:23130
    BTB; BTB/POZ domain
    cd14735
    Location:130188
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:416459
    Kelch; KELCH repeat [structural motif]
  2. NM_153128.3NP_694768.1  kelch-like protein 12 isoform 2

    See identical proteins and their annotated locations for NP_694768.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK034170, CD364043
    Consensus CDS
    CCDS35715.1
    UniProtKB/Swiss-Prot
    Q8BZM0
    Related
    ENSMUSP00000107851, OTTMUSP00000023860, ENSMUST00000112232, OTTMUST00000050879
    Conserved Domains (5) summary
    smart00612
    Location:494538
    Kelch; Kelch domain
    PHA03098
    Location:46523
    PHA03098; kelch-like protein; Provisional
    pfam00651
    Location:23130
    BTB; BTB/POZ domain
    cd14735
    Location:130188
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:319365
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    134455495..134490875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529561.1XP_006529624.1  

    See identical proteins and their annotated locations for XP_006529624.1

    UniProtKB/Swiss-Prot
    Q8BZM0
    Related
    ENSMUSP00000112227, ENSMUST00000116528
    Conserved Domains (5) summary
    smart00612
    Location:474520
    Kelch; Kelch domain
    PHA03098
    Location:46550
    PHA03098; kelch-like protein; Provisional
    pfam00651
    Location:23130
    BTB; BTB/POZ domain
    cd14735
    Location:130188
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:416459
    Kelch; KELCH repeat [structural motif]
  2. XM_006529560.2XP_006529623.1  

    Related
    ENSMUSP00000027725, OTTMUSP00000023861, ENSMUST00000027725, OTTMUST00000050880
    Conserved Domains (5) summary
    smart00612
    Location:474520
    Kelch; Kelch domain
    PHA03098
    Location:46550
    PHA03098; kelch-like protein; Provisional
    pfam00651
    Location:23130
    BTB; BTB/POZ domain
    cd14735
    Location:130188
    BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
    sd00038
    Location:416459
    Kelch; KELCH repeat [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    137062147..137097576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)