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    Taf7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor [ Mus musculus (house mouse) ]

    Gene ID: 24074, updated on 9-May-2013
    Official Symbol
    Taf7provided by MGI
    Official Full Name
    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factorprovided by MGI
    Primary source
    MGI:1346348
    See related
    Ensembl:ENSMUSG00000051316; Vega:OTTMUSG00000034268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    55kDa; Taf2f; TAFII55; AI607308; BB007175
    Location :
    18 B3; 18
    Sequence :
    Chromosome: 18; NC_000084.6 (37640491..37644204, complement)
    See Taf7 in Epigenomics, MapViewer

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene protocadherin beta 22 Neighboring gene solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2 Neighboring gene protein UXT-like Neighboring gene RIKEN cDNA 3222401L13 gene Neighboring gene predicted gene 8242 Neighboring gene predicted gene, 19748

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells. Gegonne A, et al. Mol Cell Biol, 2012 May. PMID 22411629.
    2. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595.
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953.
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. upon transcription inhibition, binding of RNA polymerase II to gene regulatory elements is severely reduced. However, contacts between regulatory DNA elements and genes in the beta-globin locus are unaffected
      Title: Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:204884 BioGRID:203978 Tbp    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    vitamin D receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    DNA-dependent transcription, initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription initiation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    transcription initiation factor TFIID subunit 7
    Names
    transcription initiation factor TFIID subunit 7
    TAFII-55
    TAF(II)55
    RNA polymerase II TBP-associated factor subunit F
    transcription initiation factor TFIID 55 kDa subunit
    TATA box binding protein (TBP) associated factor, RNA polymerase II, F, 55 kDa
    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175770.4 → NP_786964.1  transcription initiation factor TFIID subunit 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC020971, AK076362, DV656353
      Consensus CDS
      CCDS29189.1
      UniProtKB/Swiss-Prot
      Q9R1C0
      Related
      ENSMUSP00000065645, OTTMUSP00000047218, ENSMUST00000066272, OTTMUST00000087081
      Conserved Domains (1) summary
      cd08047
      Location:13 – 184
      Blast Score: 441
      TAF7; TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p1 C57BL/6J

      Range
      37640491..37644204, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      38972979..38976692, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01137784.1 (31144..34857) None
    genomic AC020971.3 (71017..77008) None
    genomic CH466528.2 EDL10146.1 mixed
    mRNA AF144562.1 AAD46767.1
    mRNA AK029380.1 BAC26429.1 C57BL/6J
    mRNA AK054206.1 None C57BL/6J
    mRNA AK075700.1 BAC35898.1 C57BL/6J
    mRNA AK076362.1 BAC36313.1 C57BL/6J
    mRNA AK089054.1 BAC40723.2 NOD
    mRNA BC029673.1 AAH29673.1 FVB/N-3
    mRNA DV656353.1 None C57BL/6J
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1C0.1 GenPept UniProtKB/Swiss-Prot:Q9R1C0

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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