Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    Dmrt3 doublesex and mab-3 related transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 240590, updated on 9-May-2013
    Official Symbol
    Dmrt3provided by MGI
    Official Full Name
    doublesex and mab-3 related transcription factor 3provided by MGI
    Primary source
    MGI:2449470
    See related
    Ensembl:ENSMUSG00000042372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Location :
    19 C1; 19
    Sequence :
    Chromosome: 19; NC_000085.6 (25610537..25623921)
    See Dmrt3 in Epigenomics, MapViewer

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5249 Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene RIKEN cDNA 2610016A17 gene Neighboring gene doublesex and mab-3 related transcription factor 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Andersson LS, et al. Nature, 2012 Aug 30. PMID 22932389.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Zagoraiou L, et al. Neuron, 2009 Dec 10. PMID 20005822.
    4. Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. Garcia-Ortiz JE, et al. BMC Dev Biol, 2009 Jun 18. PMID 19538736.
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated loco
      Title: Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    male sex differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    sex differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		  
    ventral spinal cord interneuron specification IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    doublesex- and mab-3-related transcription factor 3
    Names
    doublesex- and mab-3-related transcription factor 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177360.3 → NP_796334.2  doublesex- and mab-3-related transcription factor 3

      Status: VALIDATED

      Source sequence(s)
      AF541936, BC052041
      Consensus CDS
      CCDS29718.1
      UniProtKB/Swiss-Prot
      Q80WT2
      Related
      ENSMUSP00000046812, ENSMUST00000048935
      Conserved Domains (2) summary
      pfam03474
      Location:254 – 292
      Blast Score: 165
      DMA; DMRTA motif
      pfam00751
      Location:26 – 71
      Blast Score: 275
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p1 C57BL/6J

      Range
      25610537..25623921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      26405156..26418520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01142781.1 (58..4421) None
    genomic AAHY01142782.1 None
    genomic AC132140.3 (50836..64218) None
    genomic CH466534.1 EDL41633.1 mixed
    mRNA AF541936.1 AAN77230.1 C57BL/6J
    mRNA BC052041.1 AAH52041.2 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80WT2.2 GenPept UniProtKB/Swiss-Prot:Q80WT2

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...