Lynx1 Ly6/neurotoxin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lynx1provided by MGI
Official Full Name: Ly6/neurotoxin 1provided by MGI
Primary source: MGI:MGI:1345180
See related: Ensembl:ENSMUSG00000022594 AllianceGenome:MGI:1345180
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLURP-2
Summary: Enables acetylcholine receptor inhibitor activity and ion channel inhibitor activity. Acts upstream of or within cholinergic synaptic transmission. Located in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and respiratory system. Orthologous to several human genes including LYNX1-SLURP2 (LYNX1-SLURP2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 74.6), heart adult (RPKM 72.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.27 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74619705..74624828, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74747856..74752979, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accumulation of beta-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
Title: Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum.
The results of this study suggested greater spine loss as a better correlate of elevated functional plasticity in adult Lynx1-KO mice.
Title: Lynx1 Limits Dendritic Spine Turnover in the Adult Visual Cortex.
tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity.
Title: Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.
lynx1 KO animals over 1 year of age have clear ultrastructural differences in the striatum.
Title: Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation.
Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum
Title: Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum.
The motor learning is more sensitive to loss of lynx function.
Title: Enhancement in motor learning through genetic manipulation of the Lynx1 gene.
study identified an increase in expression of Lynx1 protein that prevented plasticity in the primary visual cortex late in life; Lynx1 expression maintains stability of mature cortical networks in the presence of cholinergic innervation
Title: Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.
Results show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs and enhances receptor desensitization, resulting in a novel type of functional modulation
Title: Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137585 (e-PCR)
- UniSTS:219672

AI838844 (e-PCR)
- UniSTS:165935

Lynx1 (e-PCR), detects polymorphism
- UniSTS:507038

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables ion channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within synaptic transmission, cholinergic	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within synaptic transmission, cholinergic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: ly-6/neurotoxin-like protein 1

Names: GC26; secreted Ly-6/uPAR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011838.4 → NP_035968.1 ly-6/neurotoxin-like protein 1 precursor

See identical proteins and their annotated locations for NP_035968.1

Status: PROVISIONAL

Source sequence(s)

AC118022

Consensus CDS

CCDS27530.1

UniProtKB/Swiss-Prot

P0DP60, Q08EF7, Q3TRB5, Q9WVC2

Related

ENSMUSP00000023259.9, ENSMUST00000023259.15

Conserved Domains (1) summary

cd00117
Location:21 → 94

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...