ALOX12 arachidonate 12-lipoxygenase [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ALOX12provided by HGNC
Official Full Name: arachidonate 12-lipoxygenaseprovided by HGNC
Primary source: HGNC:429
See related: Ensembl:ENSG00000108839; HPRD:01066; MIM:152391; Vega:OTTHUMG00000102088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LOG12; 12-LOX; 12S-LOX

Help top of page

Genomic context

Location :: 17p13.1

Sequence :: Chromosome: 17; NC_000017.10 (6899384..6914055)

See ALOX12 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

12(S)-LOX expression in inflammatory areas of colorectal tumours has the capacity to induce an invasive phenotype in colorectal cancer cells and could be targeted for therapy.
Title: Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
Overexpression of 12/15-lipoxygenase leads to increased levels of beta-secretase-1 mRNA and protein, a significant elevation in amyloid beta levels and deposition, and a worsening of memory deficits in Alzheimer's disease transgenic mice.
Title: Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
genetic variants in ALOX12 may influence BMD and fracture risk.
Title: Polymorphisms in the ALOX12 gene and osteoporosis.
This study for the first time had co-related the quantity of serum LOX-12 with breast cancer and also with the effect of chemotherapy.
Title: Evaluation of human LOX-12 as a serum marker for breast cancer.
12-LOX may serve as a unique marker and therapeutic target for prostate cancer stem cells
Title: Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells.
the rs2073438 polymorphism of ALOX12 contributes to the variation of obesity phenotypes in young Chinese men
Title: ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families.
Data suggest that the development of combinatory therapies that profit from the ACSL4, lipooxygenase and COX-2 synergistic action may allow for lower medication doses and avoidance of side effects.
Title: Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells.
Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2alpha differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Title: Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differently for cyclooxygenase-1 and 12-lipoxygenase catalysis.
Genetic absence of this enzyme results in a significant reduction in amyloid-beta (Abeta) production and deposition and an improvement of cognitive deficits.
Title: Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
the 12 and 15 ALOX expression, localization and downstream cytokine expression in subcutaneous and omental adipose tissue in human obesity were shown.
Title: Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.

Submit: New GeneRIF Correction See all (57)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_000688.1	NP_000204.3	ITGB4	BIND	PubMed	12-LOX interacts with Integrin-beta4.
NP_000688.1	NP_000415.1	KRT5	BIND	PubMed	12-LOX interacts with K5.
NP_000688.1		LMNA	BIND	PubMed	12-LOX interacts with Lamin A.
NP_000688.1	NP_079471.1	TRIB1	BIND	PubMed	12-LOX interacts with C8FW.
P18054	P16144	ITGB4	HPRD	PubMed
P18054	Q92993	KAT5	HPRD	PubMed
P18054	P13647	KRT5	HPRD	PubMed
P18054	P78386	KRT85	HPRD	PubMed
P18054	P02545	LMNA	HPRD	PubMed
P18054	P14555	PLA2G2A	HPRD	PubMed
P18054	Q96RU8	TRIB1	HPRD	PubMed
BioGRID:106740	BioGRID:109897	ITGB4	BioGRID	PubMed	Two-hybrid
BioGRID:106740	BioGRID:110050	KRT5	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:106740	BioGRID:110186	LMNA	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:106740	BioGRID:115516	TRIB1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
arachidonate 12-lipoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
hepoxilin-epoxide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
iron ion binding	IEA Inferred from Electronic Annotation more info
lipoxygenase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
anti-apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
anti-apoptosis	ISS Inferred from Sequence or Structural Similarity more info
cellular component movement	IMP Inferred from Mutant Phenotype more info	PubMed
fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
negative regulation of cell killing	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell killing	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
positive regulation of mitochondrial depolarization	IEA Inferred from Electronic Annotation more info
reactive oxygen species metabolic process	NAS Non-traceable Author Statement more info	PubMed
superoxide anion generation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: arachidonate 12-lipoxygenase, 12S-type

Names: arachidonate 12-lipoxygenase, 12S-type; platelet 12-LOX; 12S-lipoxygenase; 12(S)-lipoxygenase; platelet-type 12-lipoxygenase; platelet-type lipoxygenase 12

NP_000688.2

EC 1.13.11.31

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000697.2 → NP_000688.2 arachidonate 12-lipoxygenase, 12S-type

Status: VALIDATED

Source sequence(s)

AC040977, M58704

Consensus CDS

CCDS11084.1

UniProtKB/Swiss-Prot

P18054

Related

ENSP00000251535, OTTHUMP00000128281, ENST00000251535, OTTHUMT00000219922

Conserved Domains (2) summary

cd01753
Location:2 – 111
Blast Score: 352

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:122 – 655
Blast Score: 1701

Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

6899384..6914055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

6793203..6807748

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC040977.10 (120908..135579)	None
genomic	AY527817.1	AAS00094.1
genomic	CH471108.2	EAW90281.1
genomic	D12638.1	BAA02162.1
genomic	M87004.1	AAA51587.1
mRNA	AF143883.1	AAD32700.1
mRNA	BC069557.1	AAH69557.1
mRNA	M35418.1	AAA60056.1
mRNA	M58704.1	AAA59523.1
mRNA	M62982.1	AAA51533.1
mRNA	S68587.1	AAD14020.1
mRNA	S68588.1	AAD14021.1