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Pde4d phosphodiesterase 4D, cAMP specific [ Mus musculus (house mouse) ]

Gene ID: 238871, updated on 8-May-2016
Official Symbol
Pde4dprovided by MGI
Official Full Name
phosphodiesterase 4D, cAMP specificprovided by MGI
Primary source
MGI:MGI:99555
See related
Ensembl:ENSMUSG00000021699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpde3; 9630011N22Rik
Orthologs
Location:
13 D2.1-D2.2; 13 59.69 cM
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (108654177..109955969)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (109444371..110741682)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32450 Neighboring gene predicted gene, 27572 Neighboring gene ribosomal protein S3A3 Neighboring gene high mobility group box 3 pseudogene Neighboring gene eukaryotic translation initiation factor 4E pseudogene Neighboring gene microRNA 582 Neighboring gene predicted gene, 32813 Neighboring gene predicted gene, 32703 Neighboring gene predicted gene, 32641 Neighboring gene microRNA 1904 Neighboring gene predicted gene, 32881 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene predicted gene, 41057

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cAMP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cAMP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
PubMed 
regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ryanodine-sensitive calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Names
cAMP-specific phosphodiesterase 4D
cyclic AMP specific phosphodiesterase PDE4D5A
dunce
NP_035186.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011056.3NP_035186.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D

    See identical proteins and their annotated locations for NP_035186.1

    Status: VALIDATED

    Source sequence(s)
    AC156571, AC161585, AC163650, AC174458, CT025614
    Consensus CDS
    CCDS49359.1
    UniProtKB/Swiss-Prot
    Q01063
    UniProtKB/TrEMBL
    A2RSH1
    Related
    ENSMUSP00000113488, OTTMUSP00000042285, ENSMUST00000122041, OTTMUST00000079296
    Conserved Domains (1) summary
    cd00077
    Location:400582
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    108654177..109955969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517643.1XP_006517706.1  

    UniProtKB/TrEMBL
    E9PVU7
    Related
    ENSMUSP00000112991, OTTMUSP00000043004, ENSMUST00000120671, OTTMUST00000080693
    Conserved Domains (1) summary
    cd00077
    Location:456638
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  2. XM_006517644.2XP_006517707.1  

    Related
    ENSMUSP00000121592, OTTMUSP00000043006, ENSMUST00000153234, OTTMUST00000080695
    Conserved Domains (1) summary
    cd00077
    Location:398580
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  3. XM_006517645.2XP_006517708.1  

    UniProtKB/TrEMBL
    B2KF84
    Related
    ENSMUSP00000114089, OTTMUSP00000043026, ENSMUST00000119507, OTTMUST00000080737
    Conserved Domains (1) summary
    cd00077
    Location:356538
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  4. XM_006517646.2XP_006517709.1  

    Related
    ENSMUSP00000119583, OTTMUSP00000043027, ENSMUST00000135275, OTTMUST00000080738
    Conserved Domains (1) summary
    cd00077
    Location:339521
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  5. XM_006517647.2XP_006517710.1  

    See identical proteins and their annotated locations for XP_006517710.1

    UniProtKB/Swiss-Prot
    Q01063
    Related
    ENSMUSP00000073742, OTTMUSP00000043028, ENSMUST00000074103, OTTMUST00000080739
    Conserved Domains (1) summary
    cd00077
    Location:331513
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  6. XM_006517649.2XP_006517712.1  

    See identical proteins and their annotated locations for XP_006517712.1

    UniProtKB/TrEMBL
    A6XDA7
    Related
    ENSMUSP00000113024, OTTMUSP00000043029, ENSMUST00000120664, OTTMUST00000080741
    Conserved Domains (1) summary
    cd00077
    Location:159341
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
  7. XM_006517648.2XP_006517711.1  

    See identical proteins and their annotated locations for XP_006517711.1

    UniProtKB/TrEMBL
    A6XDB0
    Related
    ENSMUSP00000113610, OTTMUSP00000043057, ENSMUST00000117420, OTTMUST00000080781
    Conserved Domains (1) summary
    cd00077
    Location:170352
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    112976414..114290374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)