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Farsb phenylalanyl-tRNA synthetase, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 23874, updated on 8-May-2016
Official Symbol
Farsbprovided by MGI
Official Full Name
phenylalanyl-tRNA synthetase, beta subunitprovided by MGI
Primary source
MGI:MGI:1346035
See related
Ensembl:ENSMUSG00000026245 Vega:OTTMUSG00000047790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frsb; Farsa; Farsl; C76708; Farslb
Orthologs
Location:
1; 1 C4
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (78417958..78488897, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (78421411..78485421, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphotase 2 Neighboring gene predicted gene 28410 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
phenylalanine--tRNA ligase beta subunit
Names
PheRS alpha
phenylalanine tRNA synthetase alpha
phenylalanine--tRNA ligase beta chain
phenylalanine-tRNA synthetase-like, beta subunit
phenylalanyl-tRNA synthetase beta chain
NP_001265004.1
NP_035941.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278075.1NP_001265004.1  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_001265004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158559, AK012154, AK045432
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9WUA2
    UniProtKB/TrEMBL
    Q9CZU5
    Related
    ENSMUSP00000129828, OTTMUSP00000067298, ENSMUST00000170217, OTTMUST00000123029
    Conserved Domains (4) summary
    smart00874
    Location:305374
    B5; tRNA synthetase B5 domain
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
  2. NM_011811.4NP_035941.2  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_035941.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158559, AK010271, BM212593
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9WUA2
    Related
    ENSMUSP00000069508, OTTMUSP00000067299, ENSMUST00000068333, OTTMUST00000123030
    Conserved Domains (4) summary
    smart00874
    Location:305374
    B5; tRNA synthetase B5 domain
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...

RNA

  1. NR_102757.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158559, AK012154, AK045432, BM212593, CN693684
    Related
    ENSMUST00000189529, OTTMUST00000123031
  2. NR_102758.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158559, AK010271, AK134799, BM212593

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    78417958..78488897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_865550.1 RNA Sequence

Reference GRCm38.p3 129S6/SvEvTac

Genomic

  1. NT_039198.1 Reference GRCm38.p3 129S6/SvEvTac

    Range
    197223..268677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497302.2XP_006497365.1  

    Conserved Domains (4) summary
    smart00874
    Location:305374
    B5; tRNA synthetase B5 domain
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1541
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cl00268
    Location:392522
    class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    78888354..78957147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)