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    Cdc6 cell division cycle 6 homolog (S. cerevisiae) [ Mus musculus ]

    Gene ID: 23834, updated on 11-May-2012
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    Summary

    Official Symbol
    Cdc6provided by MGI
    Official Full Name
    cell division cycle 6 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:1345150
    Locus tag
    RP23-333D2.2
    See related
    Ensembl:ENSMUSG00000017499; Vega:OTTMUSG00000006454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDC18L
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    Genomic context

    Location :
    11; 11 D
    Sequence :
    Chromosome: 11; NC_000077.6 (98907889..98923942)
    See Cdc6 in Epigenomics, MapViewer

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF)-like 1 Neighboring gene WAS/WASL interacting protein family, member 2 Neighboring gene retinoic acid receptor, alpha Neighboring gene gap junction protein, delta 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. Cell proliferation in the absence of E2F1-3. Wenzel PL, et al. Dev Biol, 2011 Mar 1. PMID 21185283.
    3. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. O'Brien KB, et al. Development, 2010 Jul. PMID 20530543.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells. Zhang K, et al. J Cell Biol, 2010 Jan 11. PMID 20048262.

    See all (28) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
      Title: Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.
    2. hCdt1 and hCdc6 expression promote malignant behavior
      Title: Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
    3. CDC6 is essential for spindle formation in mouse oocytes
      Title: CDC6 requirement for spindle formation during maturation of mouse oocytes.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:204750 BioGRID:114579 AIFM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204750 BioGRID:115118 BCLAF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204750 BioGRID:107426 CDC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:204750 BioGRID:115292 THRAP3    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the Cdc6 gene: The Cdc6 gene is conserved in human, chimpanzee, , dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Human, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell cycle cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of mitotic anaphase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    cell division control protein 6 homolog
    Names
    cell division control protein 6 homolog
    p62(cdc6)
    CDC18(S.pombe)
    CDC6-related protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025779.1 → NP_001020950.1  cell division control protein 6 homolog isoform b

      Status: VALIDATED

      Source sequence(s)
      AL591067, BC052434
      Consensus CDS
      CCDS25368.1
      UniProtKB/Swiss-Prot
      O89033
      Related
      ENSMUSP00000090382, OTTMUSP00000006852, ENSMUST00000092706, OTTMUST00000014746
      Conserved Domains (3) summary
      COG1474
      Location:170 – 547
      Blast Score: 501
      CDC6; Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]
      cd00009
      Location:184 – 332
      Blast Score: 136
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cd08768
      Location:460 – 543
      Blast Score: 128
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding.

    2. NM_011799.2 → NP_035929.1  cell division control protein 6 homolog isoform a

      Status: VALIDATED

      Source sequence(s)
      AJ223087, AL591067
      Consensus CDS
      CCDS25367.1
      UniProtKB/Swiss-Prot
      O89033
      Related
      ENSMUSP00000091469, OTTMUSP00000006853, ENSMUST00000093937, OTTMUST00000014747
      Conserved Domains (3) summary
      COG1474
      Location:197 – 574
      Blast Score: 501
      CDC6; Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]
      cd00009
      Location:211 – 359
      Blast Score: 137
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cd08768
      Location:487 – 570
      Blast Score: 128
      Cdc6_C; Winged-helix domain of essential DNA replication protein Cell division control protein (Cdc6), which mediates DNA binding.

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38 C57BL/6J

      Range
      98907889..98923942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      108572996..108589050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL591067.35 (51311..67365) None
    genomic CH466556.1 EDL16173.1 mixed
      EDL16174.1 mixed
    mRNA AJ009559.1 CAA08752.1
    mRNA AJ223087.1 CAA11110.1
    mRNA AK012192.1 BAB28090.1 C57BL/6J
    mRNA AK075975.1 None C57BL/6J
    mRNA AK085020.1 BAC39341.1 C57BL/6J
    mRNA AK162669.1 None C57BL/6J
    mRNA AK166003.1 BAE38512.1
    mRNA BC052434.1 AAH52434.1 C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89033.2 GenPept UniProtKB/Swiss-Prot:O89033
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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