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Ash2l ash2 (absent, small, or homeotic)-like (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 23808, updated on 19-Sep-2014
Official Symbol
Ash2lprovided by MGI
Official Full Name
ash2 (absent, small, or homeotic)-like (Drosophila)provided by MGI
Primary source
MGI:MGI:1344416
See related
Ensembl:ENSMUSG00000031575; Vega:OTTMUSG00000022959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
See Ash2l in Epigenomics, MapViewer
Location:
8; 8 A3
Exon count:
18
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 8 NC_000074.6 (25816000..25847694, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) Neighboring gene steroidogenic acute regulatory protein Neighboring gene potassium channel, subfamily U, member 1 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone methyltransferase activity (H3-K4 specific) ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
histone H3-K4 methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
set1/Ash2 histone methyltransferase complex subunit ASH2
Names
set1/Ash2 histone methyltransferase complex subunit ASH2
ASH2-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080793.2NP_001074262.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform b

    See proteins identical to NP_001074262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC122752, AK145576, BQ769493, CV556779
    Consensus CDS
    CCDS40308.1
    UniProtKB/TrEMBL
    E9PU93
    UniProtKB/TrEMBL
    Q3UKZ9
    Conserved Domains (1) summary
    cd12872
    Location:298489
    SPRY_Ash2; SPRY domain in Ash2
  2. NM_001286207.1NP_001273136.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform c

    See proteins identical to NP_001273136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC122752, AK146599, BQ769493, CV556779
    Consensus CDS
    CCDS40308.1
    UniProtKB/TrEMBL
    E9PU93
    UniProtKB/TrEMBL
    Q3UJ62
    Conserved Domains (1) summary
    cd12872
    Location:298489
    SPRY_Ash2; SPRY domain in Ash2
  3. NM_011791.3NP_035921.2  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform a

    See proteins identical to NP_035921.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
    Source sequence(s)
    AC122752, AK146938, BQ769493, CV556779
    Consensus CDS
    CCDS40307.1
    UniProtKB/Swiss-Prot
    Q91X20
    Related
    ENSMUSP00000070957, OTTMUSP00000026421, ENSMUST00000068892, OTTMUST00000055228
    Conserved Domains (1) summary
    cd12872
    Location:387578
    SPRY_Ash2; SPRY domain in Ash2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 

    Range
    25816000..25847694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 

    Range
    27284229..27316027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)