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ZKSCAN5 zinc finger with KRAB and SCAN domains 5 [ Homo sapiens (human) ]

Gene ID: 23660, updated on 26-May-2016
Official Symbol
ZKSCAN5provided by HGNC
Official Full Name
zinc finger with KRAB and SCAN domains 5provided by HGNC
Primary source
HGNC:HGNC:12867
See related
Ensembl:ENSG00000196652 HPRD:10318; MIM:611272; Vega:OTTHUMG00000156749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP95; ZFP-95; ZNF914; ZSCAN37
Summary
This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain and may be involved in transcriptional regulation. A similar protein in mouse is differentially expressed in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Orthologs
Location:
7q22
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (99501297..99534107)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99102273..99131445)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724006 Neighboring gene zinc finger protein 789 Neighboring gene zinc finger protein 394 Neighboring gene zinc finger protein 3 pseudogene Neighboring gene uncharacterized LOC105375422 Neighboring gene family with sequence similarity 200 member A

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39233, KIAA1015, MGC33710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
zinc finger protein with KRAB and SCAN domains 5
Names
zinc finger protein 95 homolog
zinc finger protein homologous to Zfp95 in mouse

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318082.1NP_001305011.1  zinc finger protein with KRAB and SCAN domains 5 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AB023232, AF170025, BC030790, CA311067, DA572286
    UniProtKB/Swiss-Prot
    Q9Y2L8
    UniProtKB/TrEMBL
    Q8N718
    Conserved Domains (6) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07765
    Location:222257
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318762
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:388411
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:551571
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001318083.1NP_001305012.1  zinc finger protein with KRAB and SCAN domains 5 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon and lacks an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB023232, AF170025, CA311067, CX163381, DA572286
    UniProtKB/Swiss-Prot
    Q9Y2L8
    Conserved Domains (5) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:245689
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:315338
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:478498
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001318084.1NP_001305013.1  zinc finger protein with KRAB and SCAN domains 5 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AB023232, BC030790, BX648490, CA311067
    UniProtKB/Swiss-Prot
    Q9Y2L8
    UniProtKB/TrEMBL
    Q8N718
    Conserved Domains (3) summary
    COG5048
    Location:54498
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:124147
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_014569.3NP_055384.1  zinc finger protein with KRAB and SCAN domains 5 isoform a

    See identical proteins and their annotated locations for NP_055384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AB023232, AF170025, AK027714, CA311067, DA044307, DA773579
    Consensus CDS
    CCDS5667.1
    UniProtKB/Swiss-Prot
    Q9Y2L8
    UniProtKB/TrEMBL
    B3KNK8
    Related
    ENSP00000377725, OTTHUMP00000210524, ENST00000394170, OTTHUMT00000345597
    Conserved Domains (6) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07765
    Location:222257
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318762
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:388411
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:551571
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_145102.3NP_659570.1  zinc finger protein with KRAB and SCAN domains 5 isoform a

    See identical proteins and their annotated locations for NP_659570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AB023232, AF170025, CA311067, DA572286, DA580238
    Consensus CDS
    CCDS5667.1
    UniProtKB/Swiss-Prot
    Q9Y2L8
    Related
    ENSP00000322872, OTTHUMP00000210527, ENST00000326775, OTTHUMT00000345601
    Conserved Domains (6) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07765
    Location:222257
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318762
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:388411
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:551571
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    99501297..99534107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715913.2XP_006715976.1  

    See identical proteins and their annotated locations for XP_006715976.1

    UniProtKB/Swiss-Prot
    Q9Y2L8
    Conserved Domains (6) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07765
    Location:222257
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318762
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:388411
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:551571
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_005250242.2XP_005250299.1  

    Conserved Domains (5) summary
    smart00431
    Location:46155
    SCAN; leucine rich region
    cd07936
    Location:46130
    SCAN; SCAN oligomerization domain
    COG5048
    Location:245689
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:315338
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:478498
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_005250243.2XP_005250300.1  

    Conserved Domains (3) summary
    COG5048
    Location:54498
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:124147
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:287307
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011515999.1XP_011514301.1  

    Conserved Domains (4) summary
    cd07765
    Location:73108
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:169613
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:239262
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:402422
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    99032363..99061544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)