Format

Send to:

Choose Destination

PLA2G15 phospholipase A2 group XV [ Homo sapiens (human) ]

Gene ID: 23659, updated on 8-May-2016
Official Symbol
PLA2G15provided by HGNC
Official Full Name
phospholipase A2 group XVprovided by HGNC
Primary source
HGNC:HGNC:17163
See related
Ensembl:ENSG00000103066 HPRD:07128; MIM:609362; Vega:OTTHUMG00000137554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACS; LLPL; LPLA2; LYPLA3; GXVPLA2
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (68245343..68261062)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68279240..68294965)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene ribosomal protein S12 pseudogene 27 Neighboring gene microRNA 6773 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene solute carrier family 7 member 6 Neighboring gene solute carrier family 7 member 6 opposite strand Neighboring gene protein arginine methyltransferase 7 Neighboring gene sphingomyelin phosphodiesterase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp564A0122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
lysophospholipase activity TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ceramide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid catabolic process TAS
Traceable Author Statement
more info
PubMed 
glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylethanolamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosome NAS
Non-traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
group XV phospholipase A2
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
lysophospholipase 3 (lysosomal phospholipase A2)
lysosomal phospholipase A2
phospholipase A2, group XV
NP_036452.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012320.3NP_036452.1  group XV phospholipase A2 precursor

    See identical proteins and their annotated locations for NP_036452.1

    Status: REVIEWED

    Source sequence(s)
    AK074828, BC062605
    Consensus CDS
    CCDS10864.1
    UniProtKB/Swiss-Prot
    Q8NCC3
    Related
    ENSP00000219345, OTTHUMP00000174859, ENST00000219345, OTTHUMT00000268888
    Conserved Domains (2) summary
    PLN02733
    Location:122368
    PLN02733; phosphatidylcholine-sterol O-acyltransferase
    pfam02450
    Location:72396
    LCAT; Lecithin:cholesterol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    68245343..68261062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255886.2XP_005255943.1  

    See identical proteins and their annotated locations for XP_005255943.1

    UniProtKB/TrEMBL
    B4DJW4
    Related
    ENSP00000457034, OTTHUMP00000254758, ENST00000566188, OTTHUMT00000433099
    Conserved Domains (1) summary
    PLN02733
    Location:122173
    PLN02733; phosphatidylcholine-sterol O-acyltransferase
  2. XM_011522979.1XP_011521281.1  

    See identical proteins and their annotated locations for XP_011521281.1

    Conserved Domains (2) summary
    PLN02733
    Location:154400
    PLN02733; phosphatidylcholine-sterol O-acyltransferase
    pfam02450
    Location:72428
    LCAT; Lecithin:cholesterol acyltransferase
  3. XM_011522980.1XP_011521282.1  

    Related
    ENSP00000455461, OTTHUMP00000254761, ENST00000564827, OTTHUMT00000433103
    Conserved Domains (1) summary
    PLN02733
    Location:154205
    PLN02733; phosphatidylcholine-sterol O-acyltransferase

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    69687284..69702994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)