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TRIM29 tripartite motif containing 29 [ Homo sapiens (human) ]

Gene ID: 23650, updated on 26-May-2016
Official Symbol
TRIM29provided by HGNC
Official Full Name
tripartite motif containing 29provided by HGNC
Primary source
HGNC:HGNC:17274
See related
Ensembl:ENSG00000137699 HPRD:10280; MIM:610658; Vega:OTTHUMG00000140377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATDC
Summary
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (120111286..120185423, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119981994..120056237, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369527 Neighboring gene uncharacterized LOC105378956 Neighboring gene uncharacterized LOC105369529 Neighboring gene uncharacterized LOC729173 Neighboring gene uncharacterized LOC105369530 Neighboring gene out at first homolog

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.
NHGRI GWA Catalog
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 29 (TRIM29) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36085

Gene Ontology Provided by GOA

Function Evidence Code Pubs
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
tripartite motif-containing protein 29
Names
ataxia telangiectasia group D-associated protein
ataxia-telangiectasia group D-associated protein
tripartite motif protein TRIM29
tripartite motif-containing 29

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012101.3NP_036233.2  tripartite motif-containing protein 29

    See identical proteins and their annotated locations for NP_036233.2

    Status: REVIEWED

    Source sequence(s)
    AP000679, BC017352
    Consensus CDS
    CCDS8428.1
    UniProtKB/Swiss-Prot
    Q14134
    UniProtKB/TrEMBL
    A0A024R3J1
    Related
    ENSP00000343129, OTTHUMP00000179137, ENST00000341846, OTTHUMT00000277108
    Conserved Domains (2) summary
    cd00021
    Location:223260
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam03938
    Location:272355
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    120111286..120185423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542731.1XP_011541033.1  

    See identical proteins and their annotated locations for XP_011541033.1

    Conserved Domains (2) summary
    cd00021
    Location:223260
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam03938
    Location:272355
    OmpH; Outer membrane protein (OmpH-like)
  2. XM_011542730.1XP_011541032.1  

    See identical proteins and their annotated locations for XP_011541032.1

    Conserved Domains (2) summary
    cd00021
    Location:223260
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam03938
    Location:272355
    OmpH; Outer membrane protein (OmpH-like)
  3. XM_011542732.1XP_011541034.1  

    Conserved Domains (2) summary
    cd00021
    Location:223260
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam03938
    Location:272355
    OmpH; Outer membrane protein (OmpH-like)
  4. XM_011542729.1XP_011541031.1  

    See identical proteins and their annotated locations for XP_011541031.1

    Conserved Domains (2) summary
    cd00021
    Location:223260
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam03938
    Location:272355
    OmpH; Outer membrane protein (OmpH-like)
  5. XM_005271490.1XP_005271547.1  

    See identical proteins and their annotated locations for XP_005271547.1

    UniProtKB/TrEMBL
    B7Z8U9
    Related
    ENSP00000436015, OTTHUMP00000231979, ENST00000529044, OTTHUMT00000388024
    Conserved Domains (1) summary
    pfam03938
    Location:588
    OmpH; Outer membrane protein (OmpH-like)
  6. XM_011542733.1XP_011541035.1  

    Conserved Domains (1) summary
    pfam03938
    Location:588
    OmpH; Outer membrane protein (OmpH-like)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    119869439..119896308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058193.1: Suppressed sequence

    Description
    NM_058193.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.