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PLD3 phospholipase D family, member 3 [ Homo sapiens (human) ]

Gene ID: 23646, updated on 11-Sep-2014
Official Symbol
PLD3provided by HGNC
Official Full Name
phospholipase D family, member 3provided by HGNC
Primary source
HGNC:HGNC:17158
See related
Ensembl:ENSG00000105223; HPRD:07148; MIM:615698; Vega:OTTHUMG00000152736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD19; HUK4; HU-K4
Summary
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
See PLD3 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (40348395..40378485)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40854302..40884392)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cyclin N-terminal domain containing 2 Neighboring gene v-akt murine thymoma viral oncogene homolog 2 Neighboring gene microRNA 641 Neighboring gene chromosome 19 open reading frame 47 Neighboring gene microRNA 6796 Neighboring gene homeodomain interacting protein kinase 4 Neighboring gene periaxin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
glycerophospholipid biosynthetic process TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phospholipase D3
Names
phospholipase D3
hindIII K4L homolog
choline phosphatase 3
phosphatidylcholine-hydrolyzing phospholipase D3
NP_001026866.1
NP_036400.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034098.1 

    Range
    5001..35066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031696.3NP_001026866.1  phospholipase D3

    See proteins identical to NP_001026866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC000553, BC096820, BQ640152, DA370667, DB057420
    Consensus CDS
    CCDS33027.1
    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Related
    ENSP00000348901, OTTHUMP00000202325, ENST00000356508, OTTHUMT00000327722
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  2. NM_001291311.1NP_001278240.1  phospholipase D3

    See proteins identical to NP_001278240.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC000553, BC096820, BP304863, BQ640152, U60644
    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  3. NM_012268.3NP_036400.2  phospholipase D3

    See proteins identical to NP_036400.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC000553, BP304863, BQ640152, CX785201, DA370667
    Consensus CDS
    CCDS33027.1
    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Related
    ENSP00000386938, OTTHUMP00000202323, ENST00000409735, OTTHUMT00000327720
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    40348395..40378485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258705.1XP_005258762.1  

    See proteins identical to XP_005258762.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  2. XM_006723122.1XP_006723185.1  

    See proteins identical to XP_006723185.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  3. XM_006723124.1XP_006723187.1  

    See proteins identical to XP_006723187.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Related
    ENSP00000387022, OTTHUMP00000202326, ENST00000409281, OTTHUMT00000327724
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  4. XM_005258710.2XP_005258767.1  

    See proteins identical to XP_005258767.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  5. XM_005258706.2XP_005258763.1  

    See proteins identical to XP_005258763.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  6. XM_005258708.1XP_005258765.1  

    See proteins identical to XP_005258765.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  7. XM_005258704.1XP_005258761.1  

    See proteins identical to XP_005258761.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  8. XM_005258707.2XP_005258764.1  

    See proteins identical to XP_005258764.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  9. XM_006723123.1XP_006723186.1  

    See proteins identical to XP_006723186.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  10. XM_005258709.2XP_005258766.1  

    See proteins identical to XP_005258766.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Related
    ENSP00000386293, OTTHUMP00000202292, ENST00000409419, OTTHUMT00000327628
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional
  11. XM_006723121.1XP_006723184.1  

    See proteins identical to XP_006723184.1

    UniProtKB/TrEMBL
    A0A024R0Q4
    UniProtKB/Swiss-Prot
    Q8IV08
    Conserved Domains (3) summary
    cd09144
    Location:84255
    PLDc_vPLD3_1; Putative catalytic domain, repeat 1, of vertebrate phospholipase PLD3
    cd09147
    Location:291473
    PLDc_vPLD3_2; Putative catalytic domain, repeat 2, of vertebrate phospholipase PLD3
    PHA02820
    Location:77490
    PHA02820; phospholipase-D-like protein; Provisional

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    37289542..37319862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    40854014..40884087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)