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LDOC1 leucine zipper, down-regulated in cancer 1 [ Homo sapiens (human) ]

Gene ID: 23641, updated on 8-May-2016
Official Symbol
LDOC1provided by HGNC
Official Full Name
leucine zipper, down-regulated in cancer 1provided by HGNC
Primary source
HGNC:HGNC:6548
See related
Ensembl:ENSG00000182195 HPRD:02322; MIM:300402; Vega:OTTHUMG00000022558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mar7; BCUR1; Mart7
Summary
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xq27
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (141175745..141177214, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140269930..140271310, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPANX family member B1 Neighboring gene ribosomal protein L36a pseudogene Neighboring gene SPANX family member C Neighboring gene RNA binding motif protein, X-linked 2 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

  • bG82i1.9,_DNA_segment_containing_(CA)_repeat (e-PCR)

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
protein LDOC1
Names
breast cancer, up-regulated 1
leucine zipper downregulated in cancer
leucine zipper protein down-regulated in cancer cells

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012317.3NP_036449.1  protein LDOC1

    See identical proteins and their annotated locations for NP_036449.1

    Status: REVIEWED

    Source sequence(s)
    AC234778
    Consensus CDS
    CCDS14672.1
    UniProtKB/Swiss-Prot
    O95751
    Related
    ENSP00000359557, OTTHUMP00000024174, ENST00000370526, OTTHUMT00000058592

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    141175745..141177214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    140181056..140182525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)