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DAPK2 death-associated protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 23604, updated on 26-May-2016
Official Symbol
DAPK2provided by HGNC
Official Full Name
death-associated protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:2675
See related
Ensembl:ENSG00000035664 HPRD:09905; MIM:616567; Vega:OTTHUMG00000132947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP1; DRP-1
Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Orthologs
Location:
15q22.31
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (63907036..64046455, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64363614, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene uncharacterized LOC105370860 Neighboring gene family with sequence similarity 96 member A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Bladder cancer, organism-specific biosystem (from KEGG)
    Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Bladder cancer, conserved biosystem (from KEGG)
    Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
  • Caspase activation via extrinsic apoptotic signalig pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalig pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • Ligand-independent caspase activation via DCC, organism-specific biosystem (from REACTOME)
    Ligand-independent caspase activation via DCC, organism-specific biosystemIn the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC119312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of eosinophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
autophagosome lumen IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
death-associated protein kinase 2
Names
DAP kinase 2
DAP-kinase-related protein 1 beta isoform
NP_055141.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014326.3NP_055141.2  death-associated protein kinase 2

    See identical proteins and their annotated locations for NP_055141.2

    Status: REVIEWED

    Source sequence(s)
    AB018001, AC015914, AF052941
    Consensus CDS
    CCDS10188.1
    UniProtKB/Swiss-Prot
    Q9UIK4
    UniProtKB/TrEMBL
    A0A024R603
    Related
    ENSP00000408277, OTTHUMP00000163874, ENST00000457488, OTTHUMT00000256479
    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    63907036..64046455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521417.1XP_011519719.1  

    See identical proteins and their annotated locations for XP_011519719.1

    Conserved Domains (2) summary
    smart00220
    Location:23279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011521414.1XP_011519716.1  

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  3. XM_011521410.1XP_011519712.1  

    See identical proteins and their annotated locations for XP_011519712.1

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  4. XM_006720453.2XP_006720516.1  

    See identical proteins and their annotated locations for XP_006720516.1

    Conserved Domains (2) summary
    smart00220
    Location:2130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011521419.1XP_011519721.1  

    See identical proteins and their annotated locations for XP_011519721.1

    Conserved Domains (2) summary
    smart00220
    Location:2130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006720452.2XP_006720515.1  

    See identical proteins and their annotated locations for XP_006720515.1

    Conserved Domains (2) summary
    smart00220
    Location:2130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011521420.1XP_011519722.1  

    Conserved Domains (1) summary
    cl21453
    Location:887
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011521413.1XP_011519715.1  

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  9. XM_011521421.1XP_011519723.1  

    Conserved Domains (2) summary
    smart00220
    Location:2130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  10. XM_011521411.1XP_011519713.1  

    See identical proteins and their annotated locations for XP_011519713.1

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  11. XM_011521412.1XP_011519714.1  

    See identical proteins and their annotated locations for XP_011519714.1

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  12. XM_011521418.1XP_011519720.1  

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  13. XM_011521415.1XP_011519717.1  

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  14. XM_011521416.1XP_011519718.1  

    See identical proteins and their annotated locations for XP_011519718.1

    UniProtKB/Swiss-Prot
    Q9UIK4
    UniProtKB/TrEMBL
    A0A0A6YYK9
    Related
    ENSP00000484390, OTTHUMP00000248595, ENST00000612884, OTTHUMT00000418543
    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    64318568..64458052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)