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ORC3 origin recognition complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 23595, updated on 8-May-2016
Official Symbol
ORC3provided by HGNC
Official Full Name
origin recognition complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:8489
See related
Ensembl:ENSG00000135336 HPRD:05398; MIM:604972; Vega:OTTHUMG00000015179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAT; ORC3L; LATHEO
Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q14.3-q16.1
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (87590067..87667454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (88299785..88377172)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 206 Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 16 Neighboring gene solute carrier family 35 member A1 Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene akirin 2 Neighboring gene uncharacterized LOC101928911

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
    Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
  • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
    Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
  • Assembly of the ORC complex at the origin of replication, organism-specific biosystem (from REACTOME)
    Assembly of the ORC complex at the origin of replication, organism-specific biosystemIn Saccharomyces cerevisiae, the entire ORC complex is constitutively bound to the origin of replication. However, in mammalian cells, Orc1, and possibly other Orc subunits, dissociate from origins o...
  • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
    Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
  • Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
    Association of licensing factors with the pre-replicative complex, organism-specific biosystemThe eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex.
  • CDC6 association with the ORC:origin complex, organism-specific biosystem (from REACTOME)
    CDC6 association with the ORC:origin complex, organism-specific biosystemCdc6 is a regulator of DNA replication initiation in both yeasts and human cells, but its mechanism of action differs between the two systems. Genetic studies in budding yeast (S. cerevisiae) and fis...
  • CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem (from REACTOME)
    CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystemInitiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. mel...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
    Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from WikiPathways)
    Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • DNA Replication, organism-specific biosystem (from WikiPathways)
    DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
  • DNA Replication, organism-specific biosystem (from REACTOME)
    DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
  • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
    DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
  • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
    E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
  • E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystem (from REACTOME)
    E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystemUnder specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk...
  • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
    G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
  • G1/S Transition, organism-specific biosystem (from REACTOME)
    G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
  • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
    G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
  • M/G1 Transition, organism-specific biosystem (from REACTOME)
    M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystem
    Mitotic G1-G1/S phases
  • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
    Orc1 removal from chromatin, organism-specific biosystem
    Orc1 removal from chromatin
  • Origin recognition complex, organism-specific biosystem (from KEGG)
    Origin recognition complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
  • Origin recognition complex, conserved biosystem (from KEGG)
    Origin recognition complex, conserved biosystemStructural complex; Genetic information processing; Replication system
  • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
    Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
  • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
    Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
  • S Phase, organism-specific biosystem (from REACTOME)
    S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
  • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
    Switching of origins to a post-replicative state, organism-specific biosystem
    Switching of origins to a post-replicative state
  • Synthesis of DNA, organism-specific biosystem (from REACTOME)
    Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
origin recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
origin recognition complex subunit 3
Names
homolog of latheo, Drosophila
origin recognition complex subunit Latheo
origin recognition complex, subunit 3 honolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197259.1NP_001184188.1  origin recognition complex subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001184188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, resulting in a downstream AUG start codon, and also lacks three nts in an alternate splicing site in the 3' coding region, as compared to variant 1. The translation reading frame remains the same, and the resulting isoform (3) has a shorter N-terminus and lacks an internal aa, as compared to isoform 1.
    Source sequence(s)
    AK303195, BM971022, DC395106
    Consensus CDS
    CCDS56440.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000444695, ENST00000546266
    Conserved Domains (1) summary
    pfam07034
    Location:1201
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  2. NM_012381.3NP_036513.2  origin recognition complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_036513.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three nts in an alternate splicing site in the 3' coding, as compared to variant 1. The translation reading frame remains the same, and the resulting isoform (2) lacks an internal aa, as compared to isoform 1.
    Source sequence(s)
    AF125507, BM971022, DC395106
    Consensus CDS
    CCDS43486.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000376586, OTTHUMP00000016835, ENST00000392844, OTTHUMT00000041452
    Conserved Domains (1) summary
    pfam07034
    Location:19344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  3. NM_181837.2NP_862820.1  origin recognition complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_862820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC047689, BM971022, DC395106
    Consensus CDS
    CCDS5012.1
    UniProtKB/Swiss-Prot
    Q9UBD5
    Related
    ENSP00000257789, OTTHUMP00000183452, ENST00000257789, OTTHUMT00000286374
    Conserved Domains (1) summary
    pfam07034
    Location:19344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    87590067..87667454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248704.1XP_005248761.1  

    Conserved Domains (1) summary
    pfam07034
    Location:19344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  2. XM_011535651.1XP_011533953.1  

    Conserved Domains (1) summary
    pfam07034
    Location:19306
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  3. XM_011535652.1XP_011533954.1  

    Conserved Domains (1) summary
    pfam07034
    Location:19344
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  4. XM_005248706.1XP_005248763.1  

    See identical proteins and their annotated locations for XP_005248763.1

    Conserved Domains (1) summary
    pfam07034
    Location:1291
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus
  5. XM_005248705.1XP_005248762.1  

    See identical proteins and their annotated locations for XP_005248762.1

    Conserved Domains (1) summary
    pfam07034
    Location:1291
    ORC3_N; Origin recognition complex (ORC) subunit 3 N-terminus

RNA

  1. XR_942370.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    88397143..88474506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)