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HEBP2 heme binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23593, updated on 17-May-2016
Official Symbol
HEBP2provided by HGNC
Official Full Name
heme binding protein 2provided by HGNC
Primary source
HGNC:HGNC:15716
See related
Ensembl:ENSG00000051620 HPRD:09316; MIM:605825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP23; SOUL; C6orf34; C6ORF34B
Summary
The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
Orthologs
Location:
6q24
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (138404199..138421545)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138725336..138734582)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ARFGEF family member 3 Neighboring gene prostate and breast cancer overexpressed 1 Neighboring gene MARCKS-like 1 pseudogene 2 Neighboring gene microRNA 3145 Neighboring gene NHS like 1 Neighboring gene mitochondrial carrier 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of heme binding protein 2 (HEBP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of heme binding protein 2 (HEBP2; SOUL) in Jurkat cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1244

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
heme-binding protein 2
Names
placental protein 23

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050594.1 RefSeqGene

    Range
    5001..14247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001326380.1NP_001313309.1  heme-binding protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL031003, AL391669
  2. NM_001326381.1NP_001313310.1  heme-binding protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031003, AL391669
  3. NM_014320.2NP_055135.1  heme-binding protein 2 isoform 2

    See identical proteins and their annotated locations for NP_055135.1

    Status: REVIEWED

    Source sequence(s)
    AF117616, AK057928, BF974311
    Consensus CDS
    CCDS5191.1
    UniProtKB/Swiss-Prot
    Q9Y5Z4
    Related
    ENSP00000475750, OTTHUMP00000017296, ENST00000607197, OTTHUMT00000042426
    Conserved Domains (1) summary
    pfam04832
    Location:20194
    SOUL; SOUL heme-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    138404199..138421545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_942368.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    138987973..138997219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)