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Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha [ Mus musculus (house mouse) ]

Gene ID: 235542, updated on 8-May-2016
Official Symbol
Ppp2r3aprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B'', alphaprovided by MGI
Primary source
MGI:MGI:2442104
See related
Ensembl:ENSMUSG00000043154 Vega:OTTMUSG00000048434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730042E07; 3222402P14Rik
Orthologs
Location:
9; 9 E4
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (101104989..101251832, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (101007319..101154162, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene male-specific lethal 2 homolog (Drosophila) Neighboring gene male-specific lethal 2 homolog (Drosophila) Neighboring gene predicted gene, 39416 Neighboring gene predicted gene, 39415 Neighboring gene predicted gene 3121 Neighboring gene predicted gene 28979

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
    Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal musle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to mainta...
  • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling Pathway, organism-specific biosystem
    IL-6 signaling Pathway
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC29057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding, bridging ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
eye photoreceptor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell motility involved in somitogenic axis elongation ISO
Inferred from Sequence Orthology
more info
 
somatic muscle development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
NP_001154834.1
NP_742156.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161362.3NP_001154834.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

    See identical proteins and their annotated locations for NP_001154834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK042943, AK076163, AK132175, BU758090, CJ100577, CX220062
    Consensus CDS
    CCDS52900.1
    UniProtKB/TrEMBL
    B2RXC8, Q3V1Y6, Q8BXX8
    Related
    ENSMUSP00000075327, OTTMUSP00000067598, ENSMUST00000075941, OTTMUST00000124147
    Conserved Domains (1) summary
    pfam13499
    Location:9071000
    EF-hand_7; EF-hand domain pair
  2. NM_172144.3NP_742156.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_742156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct translation start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK132175, BU758090, CK621911, CX220062
    Consensus CDS
    CCDS52899.1
    UniProtKB/TrEMBL
    G3X9E8, Q3V1Y6
    Related
    ENSMUSP00000069688, OTTMUSP00000067597, ENSMUST00000066773, OTTMUST00000124146
    Conserved Domains (1) summary
    pfam13499
    Location:287380
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    101104989..101251832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511704.2XP_006511767.1  

    Conserved Domains (1) summary
    pfam13499
    Location:244337
    EF-hand_7; EF-hand domain pair

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    100640744..100786778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)