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CLCF1 cardiotrophin-like cytokine factor 1 [ Homo sapiens (human) ]

Gene ID: 23529, updated on 7-Aug-2014
Official Symbol
CLCF1provided by HGNC
Official Full Name
cardiotrophin-like cytokine factor 1provided by HGNC
Primary source
HGNC:17412
See related
Ensembl:ENSG00000175505; HPRD:09643; MIM:607672; Vega:OTTHUMG00000167669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLC; NR6; BSF3; NNT1; BSF-3; CISS2; NNT-1
Summary
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
See CLCF1 in Epigenomics, MapViewer
Location:
11q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (67364168..67374177, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67131635..67141648, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 3 Neighboring gene uncharacterized LOC100130987 Neighboring gene polymerase (DNA-directed), delta 4, accessory subunit Neighboring gene RAD9 homolog A (S. pombe) Neighboring gene protein phosphatase 1, catalytic subunit, alpha isozyme Neighboring gene TBC1 domain family, member 10C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: POLD4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ciliary neurotrophic factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ciliary neurotrophic factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of isotype switching to IgE isotypes ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CNTFR-CLCF1 complex IDA
Inferred from Direct Assay
more info
PubMed 
CRLF-CLCF1 complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
Preferred Names
cardiotrophin-like cytokine factor 1
Names
cardiotrophin-like cytokine factor 1
novel neurotrophin-1
B-cell stimulating factor 3
B-cell stimulatory factor 3
B-cell-stimulating factor 3
CRLF1 associated cytokine-like factor 1
neurotrophin-1/B-cell stimulating factor-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013377.1 

    Range
    5001..15010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166212.1NP_001159684.1  cardiotrophin-like cytokine factor 1 isoform 2 precursor

    See proteins identical to NP_001159684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AK298052, BC012939, DC393345
    Consensus CDS
    CCDS53666.1
    UniProtKB/Swiss-Prot
    Q9UBD9
    Conserved Domains (1) summary
    pfam06875
    Location:46202
    Blast Score: 147
    PRF; Plethodontid receptivity factor PRF
  2. NM_013246.2NP_037378.1  cardiotrophin-like cytokine factor 1 isoform 1 precursor

    See proteins identical to NP_037378.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Though this isoform has a predicted signal peptide at amino acids 1-27, experiments show it is retained within the cell.
    Source sequence(s)
    BC012939, BM846622
    Consensus CDS
    CCDS31617.1
    UniProtKB/Swiss-Prot
    Q9UBD9
    Related
    ENSP00000309338, OTTHUMP00000236394, ENST00000312438, OTTHUMT00000395478
    Conserved Domains (1) summary
    pfam06875
    Location:56212
    Blast Score: 148
    PRF; Plethodontid receptivity factor PRF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    67364168..67374177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    63460623..63470003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    67014667..67024689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)