My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [ Homo sapiens ]

    Gene ID: 23527, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    ACAP2provided by HGNC
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 2provided by HGNC
    Primary source
    HGNC:16469
    See related
    Ensembl:ENSG00000114331; HPRD:09681; MIM:607766; Vega:OTTHUMG00000155885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CENTB2; CNT-B2; KIAA0041
    Help top of page

    Genomic context

    Location :
    3q29
    Sequence :
    Chromosome: 3; NC_000003.11 (194995465..195163817, complement)
    See ACAP2 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507391 Neighboring gene family with sequence similarity 151, member A pseudogene Neighboring gene xyloside xylosyltransferase 1 Neighboring gene microRNA 3137 Neighboring gene ribosomal protein L31 pseudogene 22 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2 Neighboring gene ribosomal protein L24 pseudogene 6

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Substrate specificities and activities of AZAP family Arf GAPs in vivo. Cuthbert EJ, et al. Am J Physiol Cell Physiol, 2008 Jan. PMID 18003747.
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Rush J, et al. Nat Biotechnol, 2005 Jan. PMID 15592455.
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ACAP2 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1.
      Title: Substrate specificities and activities of AZAP family Arf GAPs in vivo.
    2. Centaurin beta2/KIAA0041, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity.
      Title: Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ACAP2 gene: The ACAP2 gene is conserved in chimpanzee, , dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 signaling events, organism-specific biosystem
      Arf6 signaling events
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ARF GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    regulation of ARF GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    centaurin-beta-2
    centaurin, beta 2
    Arf GAP with coiled coil, ANK repeat and PH domains 2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012287.5 → NP_036419.3  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC090018, BC017120, CA413842, D26069, DB087306
      Consensus CDS
      CCDS33924.1
      UniProtKB/Swiss-Prot
      Q15057
      Related
      ENSP00000324287, OTTHUMP00000208844, ENST00000326793, OTTHUMT00000342126
      Conserved Domains (5) summary
      cd00204
      Location:610 – 726
      Blast Score: 226
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd07638
      Location:18 – 217
      Blast Score: 880
      BAR_ACAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
      cd01250
      Location:269 – 359
      Blast Score: 355
      PH_centaurin; Centaurin Pleckstrin homology (PH) domain
      pfam12796
      Location:610 – 704
      Blast Score: 186
      Ank_2; Ankyrin repeats (3 copies)
      cl02464
      Location:402 – 517
      Blast Score: 463
      ArfGap; Putative GTPase activating protein for Arf

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      194995465..195163817, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      192371085..192539531, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC090018.12 (122678..205637) None
    genomic AC091633.22 (2090..30367) None
    genomic AC126170.6 (2004..59039) None
    genomic CH471052.2 EAW78026.1
      EAW78027.1
    mRNA AJ238248.1 CAB41450.1
    mRNA AK222635.1 None
    mRNA AK290369.1 BAF83058.1
    mRNA BC014843.1 None
    mRNA BC017120.1 None
    mRNA BC031005.1 AAH31005.1
    mRNA BC047579.1 None
    mRNA BC060767.1 AAH60767.1
    mRNA CA413842.1 None
    mRNA D26069.3 BAA05064.2
    mRNA DA774230.1 None
    mRNA DB087306.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15057.3 GenPept UniProtKB/Swiss-Prot:Q15057
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...