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FOLR3 folate receptor 3 (gamma) [ Homo sapiens (human) ]

Gene ID: 2352, updated on 8-May-2016
Official Symbol
FOLR3provided by HGNC
Official Full Name
folate receptor 3 (gamma)provided by HGNC
Primary source
HGNC:HGNC:3795
See related
Ensembl:ENSG00000110203 HPRD:03918; MIM:602469; Vega:OTTHUMG00000167870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FR-G; FR-gamma; gamma-hFR
Summary
This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Orthologs
Location:
11q13
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (72135682..72139892)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71846771..71850934)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene anaphase promoting complex subunit 15 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 6 Neighboring gene folate receptor 1 (adult) pseudogene 1 Neighboring gene folate receptor 3 (gamma) pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
folic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
folic acid transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032935.1 RefSeqGene

    Range
    4986..9168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000804.3NP_000795.2  folate receptor gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_000795.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC030285, CD368314, U08471
    Consensus CDS
    CCDS73344.1
    UniProtKB/Swiss-Prot
    P41439
    UniProtKB/TrEMBL
    A0A087WXL1
    Related
    ENSP00000481114, OTTHUMP00000276339, ENST00000611028, OTTHUMT00000396740
    Conserved Domains (1) summary
    pfam03024
    Location:36211
    Folate_rec; Folate receptor family
  2. NM_001318045.1NP_001304974.1  folate receptor gamma isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AP000812, BC030285, BI836723, CD368314, U08471
    UniProtKB/Swiss-Prot
    P41439
    Conserved Domains (1) summary
    pfam03024
    Location:1120
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    72135682..72139892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544873.1XP_011543175.1  

    See identical proteins and their annotated locations for XP_011543175.1

    UniProtKB/TrEMBL
    A0A087WXL1
    Conserved Domains (1) summary
    pfam03024
    Location:36211
    Folate_rec; Folate receptor family
  2. XM_011544875.1XP_011543177.1  

    Conserved Domains (1) summary
    pfam03024
    Location:1120
    Folate_rec; Folate receptor family
  3. XM_011544874.1XP_011543176.1  

    See identical proteins and their annotated locations for XP_011543176.1

    UniProtKB/TrEMBL
    A0A087WXL1
    Conserved Domains (1) summary
    pfam03024
    Location:36211
    Folate_rec; Folate receptor family
  4. XM_011544876.1XP_011543178.1  

    Conserved Domains (1) summary
    pfam03024
    Location:30119
    Folate_rec; Folate receptor family

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    71730576..71734739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)