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DAAM2 dishevelled associated activator of morphogenesis 2 [ Homo sapiens (human) ]

Gene ID: 23500, updated on 5-Jul-2015
Official Symbol
DAAM2provided by HGNC
Official Full Name
dishevelled associated activator of morphogenesis 2provided by HGNC
Primary source
HGNC:HGNC:18143
See related
Ensembl:ENSG00000146122; HPRD:09434; MIM:606627; Vega:OTTHUMG00000014653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ90A20A.1
Orthologs
See DAAM2 in Epigenomics, MapViewer
Location:
6p21.2
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (39792366..39904877)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (39760159..39872653)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 39 pseudogene Neighboring gene kinesin family member 6 Neighboring gene E2F transcription factor 4, p107/p130-binding pseudogene 1 Neighboring gene uncharacterized LOC105375048 Neighboring gene uncharacterized LOC100505635 Neighboring gene uncharacterized LOC102723789 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene ribosomal protein L23 pseudogene 6

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
NHGRI GWA Catalog
Genome-wide association study identifies five loci associated with lung function.
NHGRI GWA Catalog
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0381, MGC90515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
disheveled-associated activator of morphogenesis 2
Names
dishevelled-associated activator of morphogenesis 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201427.1NP_001188356.1  disheveled-associated activator of morphogenesis 2 isoform 1

    See identical proteins and their annotated locations for NP_001188356.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site at the 5' end of a coding exon compared to isoform 1. The resulting variant (1) encodes the longer isoform.
    Source sequence(s)
    AB002379, AW273797
    Consensus CDS
    CCDS56426.1
    UniProtKB/Swiss-Prot
    Q86T65
    Related
    ENSP00000274867, OTTHUMP00000016351, ENST00000274867, OTTHUMT00000040464
    Conserved Domains (3) summary
    pfam02181
    Location:595969
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. NM_015345.3NP_056160.2  disheveled-associated activator of morphogenesis 2 isoform 2

    See identical proteins and their annotated locations for NP_056160.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site at the 5' end of a coding exon compared to isoform 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AB002379, AL596701, AL833083, AW273797
    Consensus CDS
    CCDS54999.1
    UniProtKB/Swiss-Prot
    Q86T65
    Related
    ENSP00000437808, ENST00000538976
    Conserved Domains (3) summary
    pfam02181
    Location:595968
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    39792366..39904877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715043.1XP_006715106.1  

    See identical proteins and their annotated locations for XP_006715106.1

    Conserved Domains (3) summary
    pfam02181
    Location:595978
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. XM_006715046.2XP_006715109.1  

    See identical proteins and their annotated locations for XP_006715109.1

    Conserved Domains (3) summary
    pfam02181
    Location:595978
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain
  3. XM_011514447.1XP_011512749.1  

    Conserved Domains (3) summary
    pfam02181
    Location:6181001
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:254460
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:64251
    Drf_GBD; Diaphanous GTPase-binding Domain
  4. XM_006715042.1XP_006715105.1  

    See identical proteins and their annotated locations for XP_006715105.1

    Conserved Domains (3) summary
    pfam02181
    Location:595978
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain
  5. XM_006715039.2XP_006715102.2  

    Conserved Domains (3) summary
    pfam02181
    Location:6421025
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278484
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:88275
    Drf_GBD; Diaphanous GTPase-binding Domain
  6. XM_006715040.2XP_006715103.2  

    Conserved Domains (3) summary
    pfam02181
    Location:6421016
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:278484
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:88275
    Drf_GBD; Diaphanous GTPase-binding Domain
  7. XM_006715045.2XP_006715108.1  

    See identical proteins and their annotated locations for XP_006715108.1

    Conserved Domains (3) summary
    pfam02181
    Location:595978
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain
  8. XM_006715044.2XP_006715107.1  

    See identical proteins and their annotated locations for XP_006715107.1

    Conserved Domains (3) summary
    pfam02181
    Location:595978
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:231437
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:41228
    Drf_GBD; Diaphanous GTPase-binding Domain

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    39762775..39875249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)