Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    DAAM2 dishevelled associated activator of morphogenesis 2 [ Homo sapiens (human) ]

    Gene ID: 23500, updated on 26-Feb-2013
    Official Symbol
    DAAM2provided by HGNC
    Official Full Name
    dishevelled associated activator of morphogenesis 2provided by HGNC
    Primary source
    HGNC:18143
    Locus tag
    RP1-278E11.1
    See related
    Ensembl:ENSG00000146122; HPRD:09434; MIM:606627; Vega:OTTHUMG00000014653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ90A20A.1; RP1-278E11.1
    Location :
    6p21.2
    Sequence :
    Chromosome: 6; NC_000006.11 (39760159..39872653)
    See DAAM2 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 39 pseudogene Neighboring gene kinesin family member 6 Neighboring gene E2F transcription factor 4, p107/p130-binding pseudogene 1 Neighboring gene uncharacterized LOC100505635 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene ribosomal protein L23 pseudogene 6 Neighboring gene tubulin, beta class I pseudogene 9

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Genome-wide association study identifies five loci associated with lung function. Repapi E, et al. Nat Genet, 2010 Jan. PMID 20010834.
    2. Wnt antagonist gene polymorphisms and renal cancer. Hirata H, et al. Cancer, 2009 Oct 1. PMID 19562778.
    3. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404.
    4. Identification and characterization of human DAAM2 gene in silico. Katoh M, et al. Int J Oncol, 2003 Apr. PMID 12632087.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Wnt antagonist gene polymorphisms and renal cancer.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA0381, MGC90515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    disheveled-associated activator of morphogenesis 2
    Names
    disheveled-associated activator of morphogenesis 2
    dishevelled-associated activator of morphogenesis 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201427.1 → NP_001188356.1  disheveled-associated activator of morphogenesis 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site at the 5' end of a coding exon compared to isoform 1. The resulting variant (1) encodes the longer isoform.
      Source sequence(s)
      AB002379, AW273797
      Consensus CDS
      CCDS56426.1
      UniProtKB/Swiss-Prot
      Q86T65
      Related
      ENSP00000274867, OTTHUMP00000016351, ENST00000274867, OTTHUMT00000040464
      Conserved Domains (4) summary
      smart00498
      Location:596 – 974
      Blast Score: 733
      FH2; Formin Homology 2 Domain
      pfam02181
      Location:595 – 969
      Blast Score: 1006
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231 – 437
      Blast Score: 527
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:41 – 228
      Blast Score: 450
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_015345.3 → NP_056160.2  disheveled-associated activator of morphogenesis 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site at the 5' end of a coding exon compared to isoform 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AB002379, AL596701, AL833083, AW273797
      Consensus CDS
      CCDS54999.1
      UniProtKB/TrEMBL
      G5EA45
      UniProtKB/Swiss-Prot
      Q86T65
      Related
      ENSP00000437808, ENST00000538976
      Conserved Domains (4) summary
      smart00498
      Location:596 – 973
      Blast Score: 736
      FH2; Formin Homology 2 Domain
      pfam02181
      Location:595 – 968
      Blast Score: 992
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231 – 437
      Blast Score: 528
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:41 – 228
      Blast Score: 451
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      39760159..39872653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      39535788..39590470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      39670727..39783022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01050773.1 (21703..76385) None
    genomic AL136089.15 CAI20010.2
    genomic AL161439.15 None
    genomic AL357412.1 (2001..2861) None
    genomic AL590999.7 (2001..48339) None
    genomic AL592158.14 (2001..38304) None
    genomic AMYH01016289.1 (23977..136272) None
    genomic CH471081.1 EAX03995.1
      EAX03996.1
    genomic FO393411.1 None
    mRNA AB002379.2 BAA20835.2
    mRNA AK310941.1 None
    mRNA AL596701.1 None
    mRNA AL833083.2 CAD89973.1
    mRNA AW273797.1 None
    mRNA BC014275.2 None
    mRNA BC047555.1 None
    mRNA BC047575.1 None
    mRNA BC078153.1 AAH78153.1
    mRNA BC128388.1 None
    mRNA BX647839.1 None
    mRNA M78573.1 None
    other-genetic EU831906.1 ACE87347.1
    other-genetic EU832000.1 ACE86663.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86T65.3 GenPept UniProtKB/Swiss-Prot:Q86T65

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...