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    Acsm2 acyl-CoA synthetase medium-chain family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 233799, updated on 4-May-2013
    Official Symbol
    Acsm2provided by MGI
    Official Full Name
    acyl-CoA synthetase medium-chain family member 2provided by MGI
    Primary source
    MGI:2385289
    See related
    Ensembl:ENSMUSG00000030945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI315615; BC031140
    Location :
    7 F2; 7
    Sequence :
    Chromosome: 7; NC_000073.6 (119554340..119600694)
    See Acsm2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase-like, testis expressed Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene predicted gene, 19950 Neighboring gene acyl-CoA synthetase medium-chain family member 1 Neighboring gene acyl-CoA synthetase medium-chain family member 4

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376.
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015.
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~50%.
      Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
    Submit: New GeneRIF Correction

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC37245

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    butyrate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    medium-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    acyl-coenzyme A synthetase ACSM2, mitochondrial
    Names
    acyl-coenzyme A synthetase ACSM2, mitochondrial
    butyrate--CoA ligase 2
    butyryl coenzyme A synthetase 2
    butyryl-coenzyme A synthetase 2
    middle-chain acyl-CoA synthetase 2
    NP_001171448.1
    NP_001171449.1
    NP_666309.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177977.1 → NP_001171448.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC134587, AK140827, AK165449
      Consensus CDS
      CCDS52379.1
      UniProtKB/Swiss-Prot
      Q8K0L3
      Related
      ENSMUSP00000095690, ENSMUST00000098084
      Conserved Domains (3) summary
      COG0365
      Location:65 – 591
      Blast Score: 1031
      Acs; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
      pfam00501
      Location:107 – 519
      Blast Score: 785
      AMP-binding; AMP-binding enzyme
      pfam13193
      Location:564 – 595
      Blast Score: 118
      DUF4009; Domain of unknown function (DUF4009)

    2. NM_001177978.1 → NP_001171449.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC125147, AC134587, AK165401, AK165449
      Consensus CDS
      CCDS52380.1
      UniProtKB/Swiss-Prot
      Q8K0L3
      Related
      ENSMUSP00000126670, ENSMUST00000167935
      Conserved Domains (3) summary
      COG0365
      Location:40 – 571
      Blast Score: 1018
      Acs; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
      pfam00501
      Location:82 – 499
      Blast Score: 770
      AMP-binding; AMP-binding enzyme
      pfam13193
      Location:544 – 575
      Blast Score: 118
      DUF4009; Domain of unknown function (DUF4009)

    3. NM_146197.4 → NP_666309.1  acyl-coenzyme A synthetase ACSM2, mitochondrial isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC125147, AC134587, AK165353, AK165449
      Consensus CDS
      CCDS21782.1
      UniProtKB/Swiss-Prot
      Q8K0L3
      Conserved Domains (3) summary
      COG0365
      Location:40 – 566
      Blast Score: 1033
      Acs; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]
      pfam00501
      Location:82 – 494
      Blast Score: 786
      AMP-binding; AMP-binding enzyme
      pfam13193
      Location:539 – 570
      Blast Score: 118
      DUF4009; Domain of unknown function (DUF4009)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p1 C57BL/6J

      Range
      119554340..119600694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      119472012..119518406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01065959.1 (27395..57645) None
    genomic AAHY01065960.1 None
    genomic AC125147.4 (172762..184180) None
    genomic AC134587.3 (27916..54910) None
    genomic CH466531.1 EDL17169.1 mixed
      EDL17170.1 mixed
      EDL17171.1 mixed
      EDL17172.1 mixed
    mRNA AK057650.1 BAB71542.1
    mRNA AK140827.1 BAE24490.1 C57BL/6J
    mRNA AK143757.1 BAE25526.1 C57BL/6J
    mRNA AK165353.1 BAE38146.1 C57BL/6J
    mRNA AK165401.1 BAE38163.1 C57BL/6J
    mRNA AK165449.1 None C57BL/6J
    mRNA BC024424.1 AAH24424.1 FVB/N
    mRNA BC024450.1 AAH24450.1 FVB/N
    mRNA BC031140.1 AAH31140.1 FVB/N
    mRNA BC034445.1 None FVB/N
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0L3.1 GenPept UniProtKB/Swiss-Prot:Q8K0L3

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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