Format

Send to:

Choose Destination

Picalm phosphatidylinositol binding clathrin assembly protein [ Mus musculus (house mouse) ]

Gene ID: 233489, updated on 28-May-2016
Official Symbol
Picalmprovided by MGI
Official Full Name
phosphatidylinositol binding clathrin assembly proteinprovided by MGI
Primary source
MGI:MGI:2385902
See related
Ensembl:ENSMUSG00000039361 Vega:OTTMUSG00000059751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CALM; CLTH; fit1; fit-1; PAP180; mKIAA4114
Orthologs
Location:
7 E1; 7 50.47 cM
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (90130220..90209447)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (97278742..97357442)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310010J17 gene Neighboring gene basic transcription factor 3 pseudogene Neighboring gene coiled-coil domain containing 83 Neighboring gene synaptotagmin-like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4114, MGC19382, MGC36413, MGC36616

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
clathrin adaptor activity ISO
Inferred from Sequence Orthology
more info
 
clathrin binding ISO
Inferred from Sequence Orthology
more info
 
clathrin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cargo loading into vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cargo loading into vesicle ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
clathrin-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endosomal transport ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
iron ion import into cell ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of beta-amyloid formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of beta-amyloid formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with clathrin coat of coated pit ISO
Inferred from Sequence Orthology
more info
 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
coated pit IDA
Inferred from Direct Assay
more info
PubMed 
coated pit ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phosphatidylinositol-binding clathrin assembly protein
Names
clathrin assembly lymphoid myeloid leukemia

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252520.1NP_001239449.1  phosphatidylinositol-binding clathrin assembly protein isoform 2

    See identical proteins and their annotated locations for NP_001239449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC158781, AK220291, BK001028
    UniProtKB/Swiss-Prot
    Q7M6Y3
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000051092, OTTMUSP00000076261, ENSMUST00000049537, OTTMUST00000146473
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  2. NM_001252521.1NP_001239450.1  phosphatidylinositol-binding clathrin assembly protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC158781, AK220291, BK001028
    UniProtKB/Swiss-Prot
    Q7M6Y3
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000147016, OTTMUSP00000076260, ENSMUST00000208742, OTTMUST00000146472
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  3. NM_001252522.1NP_001239451.1  phosphatidylinositol-binding clathrin assembly protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC158781, AK220291, BK001028
    UniProtKB/Swiss-Prot
    Q7M6Y3
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146386, OTTMUSP00000076258, ENSMUST00000209068, OTTMUST00000146467
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  4. NM_001252523.1NP_001239452.1  phosphatidylinositol-binding clathrin assembly protein isoform 5

    See identical proteins and their annotated locations for NP_001239452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC158781, AK220291, BK001028
    UniProtKB/Swiss-Prot
    Q7M6Y3
    UniProtKB/TrEMBL
    Q570Z8
    Related
    ENSMUSP00000146541, OTTMUSP00000076259, ENSMUST00000208730, OTTMUST00000146470
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  5. NM_001252524.1NP_001239453.1  phosphatidylinositol-binding clathrin assembly protein isoform 6

    See identical proteins and their annotated locations for NP_001239453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons and uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC158781, AK220291, BK001028
    UniProtKB/Swiss-Prot
    Q7M6Y3
    UniProtKB/TrEMBL
    Q3TD51, Q570Z8
    Related
    ENSMUSP00000146659, OTTMUSP00000076256, ENSMUST00000207225, OTTMUST00000146465
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  6. NM_146194.4NP_666306.2  phosphatidylinositol-binding clathrin assembly protein isoform 1

    See identical proteins and their annotated locations for NP_666306.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC158781, BK001028, BY160265
    Consensus CDS
    CCDS52307.1
    UniProtKB/Swiss-Prot
    Q7M6Y3
    Related
    ENSMUSP00000146501, OTTMUSP00000076257, ENSMUST00000207484, OTTMUST00000146466
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    90130220..90209447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507594.2XP_006507657.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  2. XM_006507597.2XP_006507660.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  3. XM_006507595.2XP_006507658.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  4. XM_006507598.2XP_006507661.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  5. XM_006507601.2XP_006507664.1  

    See identical proteins and their annotated locations for XP_006507664.1

    Related
    ENSMUSP00000146509, OTTMUSP00000076263, ENSMUST00000207084, OTTMUST00000146475
    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  6. XM_006507596.2XP_006507659.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  7. XM_006507599.2XP_006507662.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  8. XM_006507600.2XP_006507663.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  9. XM_006507602.2XP_006507665.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  10. XM_006507604.2XP_006507667.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  11. XM_006507603.2XP_006507666.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...
  12. XM_006507605.2XP_006507668.1  

    Conserved Domains (1) summary
    cd03564
    Location:22138
    ANTH_AP180_CALM; ANTH domain family; composed of adaptor protein 180 (AP180), clathrin assembly lymphoid myeloid leukemia protein (CALM) and similar proteins. A set of proteins previously designated as harboring an ENTH domain in fact contains a highly similar, yet ...

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    87455394..87535053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)