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DOCK9 dedicator of cytokinesis 9 [ Homo sapiens (human) ]

Gene ID: 23348, updated on 15-May-2016
Official Symbol
DOCK9provided by HGNC
Official Full Name
dedicator of cytokinesis 9provided by HGNC
Primary source
HGNC:HGNC:14132
See related
Ensembl:ENSG00000088387 HPRD:09542; MIM:607325; Vega:OTTHUMG00000017260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIZ1; ZIZIMIN1
Orthologs
Location:
13q32.3
Exon count:
62
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (98793487..99088618, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99445741..99738660, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 15 member 1 Neighboring gene uncharacterized LOC105370330 Neighboring gene DOCK9 antisense RNA 1 Neighboring gene ribosomal protein L7 like 1 pseudogene 12 Neighboring gene RNA, U6 small nuclear 83, pseudogene Neighboring gene DOCK9 antisense RNA 2 (head to head) Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 22 Neighboring gene ribosomal protein S6 pseudogene 23

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11949, FLJ16744, FLJ44528, FLJ45282, FLJ45601, KIAA1058, KIAA1085, DKFZp686D2047, DKFZp686C11110, DKFZp686N04132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dedicator of cytokinesis protein 9
Names
cdc42 guanine nucleotide exchange factor zizimin-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130048.1NP_001123520.1  dedicator of cytokinesis protein 9 isoform b

    See identical proteins and their annotated locations for NP_001123520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a distinct N-terminus that is 1 aa shorter than that of isoform a.
    Source sequence(s)
    AB028981, AK127215, BC043506, BM968821, DB277756
    Consensus CDS
    CCDS45062.1
    UniProtKB/Swiss-Prot
    Q9BZ29
    UniProtKB/TrEMBL
    B3KXE2
    Related
    ENSP00000365643, OTTHUMP00000018601, ENST00000376460, OTTHUMT00000045566
    Conserved Domains (4) summary
    cd08697
    Location:638827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16112062
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:59153
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:169292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  2. NM_001130049.1NP_001123521.1  dedicator of cytokinesis protein 9 isoform c

    See identical proteins and their annotated locations for NP_001123521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF527605, AW450751, BC146814
    Consensus CDS
    CCDS76645.1
    UniProtKB/Swiss-Prot
    Q9BZ29
    UniProtKB/TrEMBL
    A0A0A0MT38, A6H8Z6
    Related
    ENSP00000413781, OTTHUMP00000018602, ENST00000427887, OTTHUMT00000045567
    Conserved Domains (3) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  3. NM_001130050.1NP_001123522.1  dedicator of cytokinesis protein 9 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 5' coding region, and 3' UTR, and lacks several exons in the 3' coding region, compared to variant 1. The resulting isoform (d) has distinct N- and C-termini, and is shorter than isoform a.
    Source sequence(s)
    AB028981, AK126492, AW450751
    Consensus CDS
    CCDS45063.1
    UniProtKB/Swiss-Prot
    Q9BZ29
    Related
    ENSP00000487551, OTTHUMP00000278551, ENST00000627024, OTTHUMT00000045573
    Conserved Domains (3) summary
    cd08697
    Location:638827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:59153
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:169292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  4. NM_001318849.1NP_001305778.1  dedicator of cytokinesis protein 9 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (e) is shorter than isoform a.
    Source sequence(s)
    AF527605, AK294705, BC136274, BX648707
    UniProtKB/Swiss-Prot
    Q9BZ29
    UniProtKB/TrEMBL
    B7Z2G6, B9EG73
    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16122040
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  5. NM_015296.2NP_056111.1  dedicator of cytokinesis protein 9 isoform a

    See identical proteins and their annotated locations for NP_056111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AF527605, AK127215, BC043506, BM968821
    UniProtKB/Swiss-Prot
    Q9BZ29
    UniProtKB/TrEMBL
    B3KXE2
    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16122063
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    98793487..99088618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521063.1XP_011519365.1  

    Conserved Domains (4) summary
    cd08697
    Location:631820
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16272078
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:52146
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:162285
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  2. XM_005254035.2XP_005254092.1  

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16042018
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  3. XM_006719937.2XP_006720000.1  

    Related
    ENSP00000401958, ENST00000448493
    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16122040
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  4. XM_005254036.2XP_005254093.1  

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16122040
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  5. XM_006719931.2XP_006719994.1  

    See identical proteins and their annotated locations for XP_006719994.1

    Related
    ENSP00000341086, ENST00000339416
    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16122063
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  6. XM_005254034.2XP_005254091.1  

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16352049
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  7. XM_006719924.2XP_006719987.1  

    Conserved Domains (4) summary
    cd08697
    Location:639828
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16352086
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:60154
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:170293
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  8. XM_006719938.1XP_006720001.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16152029
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  9. XM_006719930.1XP_006719993.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16152066
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  10. XM_006719936.1XP_006719999.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16232051
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  11. XM_006719928.1XP_006719991.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16232074
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  12. XM_006719933.1XP_006719996.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462060
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  13. XM_006719929.1XP_006719992.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462072
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  14. XM_006719927.1XP_006719990.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462074
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  15. XM_006719926.1XP_006719989.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462083
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  16. XM_006719923.1XP_006719986.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462095
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  17. XM_006719922.1XP_006719985.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462097
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  18. XM_006719935.1XP_006719998.1  

    Conserved Domains (4) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16462097
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  19. XM_006719932.1XP_006719995.1  

    Related
    ENSP00000406883, ENST00000442173
    Conserved Domains (4) summary
    cd08697
    Location:638827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16112062
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:59153
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:169292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  20. XM_006719925.1XP_006719988.1  

    Conserved Domains (4) summary
    cd08697
    Location:638827
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11698
    Location:16342085
    DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
    pfam11878
    Location:59153
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:169292
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  21. XM_011521064.1XP_011519366.1  

    Conserved Domains (3) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  22. XM_006719941.1XP_006720004.1  

    Conserved Domains (3) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
  23. XM_006719942.2XP_006720005.1  

    Conserved Domains (3) summary
    cd08697
    Location:650839
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:71165
    DUF3398; Domain of unknown function (DUF3398)
    cd13267
    Location:181304
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    99415461..99708407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)