These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_012855.1 RefSeqGene
- Range
- 5001..520716
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_033071.3 → NP_149062.1 nesprin-1 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter protein (isoform 2 which has also been referred to as the longer isoform), compared to isoform 1.
- Source sequence(s)
-
AF535142, AL078582
- Consensus CDS
-
CCDS5235.1
- UniProtKB/Swiss-Prot
-
Q8NF91
- Related
- ENSP00000396024, OTTHUMP00000017440, ENST00000423061, OTTHUMT00000042732
- Conserved Domains (6) summary
-
- cd00014
Location:28 – 141
Blast Score: 174
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00176
Location:7929 – 8139
Blast Score: 195
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- COG0419
Location:3733 – 4302
Blast Score: 110
- SbcC; ATPase involved in DNA repair [DNA replication, recombination, and repair]
- COG1196
Location:1423 – 2276
Blast Score: 174
- Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
- TIGR02168
Location:754 – 1007
Blast Score: 109
- SMC_prok_B; chromosome segregation protein SMC, common bacterial type
- pfam10541
Location:8719 – 8748
Blast Score: 164
- KASH; Nuclear envelope localisation domain
-
NM_182961.3 → NP_892006.3 nesprin-1 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1 which has also been referred to as the longest isoform).
- Source sequence(s)
-
AF495910, AL078582, AL136079, AL138832, AL357081, AL589963
- Consensus CDS
-
CCDS5236.2
- UniProtKB/TrEMBL
-
E7EQI5
- UniProtKB/Swiss-Prot
-
Q8NF91
- Related
- ENSP00000356224, OTTHUMP00000205471, ENST00000367255, OTTHUMT00000334755
- Conserved Domains (5) summary
-
- cd00014
Location:28 – 134
Blast Score: 192
- CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
- cd00176
Location:8000 – 8210
Blast Score: 194
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- COG1196
Location:1416 – 2269
Blast Score: 173
- Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
- TIGR02168
Location:747 – 1000
Blast Score: 109
- SMC_prok_B; chromosome segregation protein SMC, common bacterial type
- pfam10541
Location:8767 – 8796
Blast Score: 164
- KASH; Nuclear envelope localisation domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000006.11 Reference GRCh37.p5 Primary Assembly
- Range
- 152442819..152958534, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000138.1 Alternate HuRef
- Range
- 150004601..150521666, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_001099267.1: Suppressed sequence
- Description
- NM_001099267.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
-
NM_001134379.1: Suppressed sequence
- Description
- NM_001134379.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
-
NM_015293.2: Suppressed sequence
- Description
- NM_015293.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
-
NM_133650.2: Suppressed sequence
- Description
- NM_133650.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.