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Lrrk1 leucine-rich repeat kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 233328, updated on 28-May-2016
Official Symbol
Lrrk1provided by MGI
Official Full Name
leucine-rich repeat kinase 1provided by MGI
Primary source
MGI:MGI:2142227
See related
Ensembl:ENSMUSG00000015133 Vega:OTTMUSG00000024885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW319595; mKIAA1790; C230002E15Rik; D130026O16Rik
Orthologs
Location:
7; 7 C
Exon count:
37
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (66258745..66388341, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (73403631..73533227, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene VCP-interacting membrane protein Neighboring gene chondroitin sulfate synthase 1 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene predicted gene, 33442 Neighboring gene microRNA 7057 Neighboring gene aldehyde dehydrogenase family 1, subfamily A3 Neighboring gene predicted gene, 33515

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC28646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast development IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
leucine-rich repeat serine/threonine-protein kinase 1
Names
lrrk1
NP_666303.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146191.3NP_666303.3  leucine-rich repeat serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_666303.3

    Status: VALIDATED

    Source sequence(s)
    AK040153, AK076432, BC066159, BC072664, BY024941
    Consensus CDS
    CCDS21344.1
    UniProtKB/Swiss-Prot
    Q3UHC2
    Related
    ENSMUSP00000015277, OTTMUSP00000030034, ENSMUST00000015277, OTTMUST00000061293
    Conserved Domains (9) summary
    cd00116
    Location:273488
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00204
    Location:91214
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00069
    Location:12471525
    Pkinase; Protein kinase domain
    pfam12796
    Location:91180
    Ank_2; Ankyrin repeats (3 copies)
    pfam13855
    Location:302364
    LRR_8; Leucine rich repeat
    cd14067
    Location:12481523
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    TIGR00231
    Location:639820
    small_GTP; small GTP-binding protein domain
    sd00033
    Location:281303
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:639821
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    66258745..66388341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540839.2XP_006540902.1  

    Conserved Domains (9) summary
    cd00116
    Location:256471
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00204
    Location:74197
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00069
    Location:12301508
    Pkinase; Protein kinase domain
    pfam12796
    Location:74163
    Ank_2; Ankyrin repeats (3 copies)
    pfam13855
    Location:285347
    LRR_8; Leucine rich repeat
    cd14067
    Location:12311506
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    TIGR00231
    Location:622803
    small_GTP; small GTP-binding protein domain
    sd00033
    Location:264286
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:622804
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006540838.2XP_006540901.1  

    Conserved Domains (9) summary
    cd00116
    Location:274489
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00204
    Location:92215
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00069
    Location:12481526
    Pkinase; Protein kinase domain
    pfam12796
    Location:92181
    Ank_2; Ankyrin repeats (3 copies)
    pfam13855
    Location:303365
    LRR_8; Leucine rich repeat
    cd14067
    Location:12491524
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    TIGR00231
    Location:640821
    small_GTP; small GTP-binding protein domain
    sd00033
    Location:282304
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:640822
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_006540840.2XP_006540903.1  

    Conserved Domains (6) summary
    COG4886
    Location:575
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    pfam00069
    Location:709987
    Pkinase; Protein kinase domain
    cd14067
    Location:710985
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    TIGR00231
    Location:101282
    small_GTP; small GTP-binding protein domain
    sd00033
    Location:1234
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:101283
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_006540841.1XP_006540904.1  

    Conserved Domains (3) summary
    pfam00069
    Location:542820
    Pkinase; Protein kinase domain
    cd14067
    Location:543818
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    cl21455
    Location:6116
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_391340.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    59723311..59724078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. AC_000029.1 Alternate Mm_Celera

    Range
    63712568..63843036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. NW_001031130.1 Alternate Mm_Celera

    Range
    9804..10463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)