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DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 [ Homo sapiens (human) ]

Gene ID: 23317, updated on 8-May-2016
Official Symbol
DNAJC13provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C13provided by HGNC
Primary source
HGNC:HGNC:30343
See related
Ensembl:ENSG00000138246 HPRD:10915; MIM:614334; Vega:OTTHUMG00000159674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RME8; PARK21
Orthologs
Location:
3q22.1
Exon count:
57
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (132417532..132539032)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (132136361..132257876)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene g2/M phase-specific E3 ubiquitin-protein ligase-like Neighboring gene NIP7, nucleolar pre-rRNA processing protein pseudogene 2 Neighboring gene NPHP3-ACAD11 readthrough (NMD candidate) Neighboring gene acyl-CoA dehydrogenase family member 11 Neighboring gene atypical chemokine receptor 4 Neighboring gene heat shock protein family A (Hsp70) member pseudogene 19

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Parkinson disease 21
MedGen: CN230317 OMIM: 616361 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25863, KIAA0678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of early endosome to recycling endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with WASH complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dnaJ homolog subfamily C member 13
Names
DnaJ (Hsp40) homolog, subfamily C, member 13
DnaJ domain-containing protein RME-8
RME-8
required for receptor-mediated endocytosis 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015268.3NP_056083.3  dnaJ homolog subfamily C member 13

    See identical proteins and their annotated locations for NP_056083.3

    Status: VALIDATED

    Source sequence(s)
    AI189887, AY779857
    Consensus CDS
    CCDS33857.1
    UniProtKB/Swiss-Prot
    O75165
    Related
    ENSP00000260818, OTTHUMP00000216167, ENST00000260818, OTTHUMT00000356807
    Conserved Domains (2) summary
    cd06257
    Location:13011354
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam14237
    Location:9751020
    DUF4339; Domain of unknown function (DUF4339)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    132417532..132539032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247245.3XP_005247302.1  

    Conserved Domains (2) summary
    cd06257
    Location:13061359
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    pfam14237
    Location:9801025
    DUF4339; Domain of unknown function (DUF4339)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    132099536..132220871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)