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Zfp420 zinc finger protein 420 [ Mus musculus (house mouse) ]

Gene ID: 233058, updated on 21-Apr-2024

Summary

Official Symbol
Zfp420provided by MGI
Official Full Name
zinc finger protein 420provided by MGI
Primary source
MGI:MGI:2444666
See related
Ensembl:ENSMUSG00000058402 AllianceGenome:MGI:2444666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mszf70; mszf59-1; B230119D13; B230312I18Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human ZNF420 (zinc finger protein 420). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 3.8), whole brain E14.5 (RPKM 2.7) and 19 other tissues See more
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Genomic context

Location:
7 B1; 7 17.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29559392..29576727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29859967..29877302)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18491 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30601028-30601137 Neighboring gene zinc finger protein 790 Neighboring gene zinc finger protein 940 Neighboring gene STARR-positive B cell enhancer ABC_E8836 Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364618.1NP_001351547.1  zinc finger protein 420

    Status: VALIDATED

    Source sequence(s)
    AC149283, AK045435, AK045821, BY069284, BY259697, CD807409
    Consensus CDS
    CCDS52175.1
    UniProtKB/TrEMBL
    Q7TMN8
    Related
    ENSMUSP00000056077.7, ENSMUST00000057652.7
    Conserved Domains (3) summary
    COG5048
    Location:23462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:519544
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001364619.1NP_001351548.1  zinc finger protein 420

    Status: VALIDATED

    Source sequence(s)
    AC149283, AK045435, AK045821, BY069284, BY259697, CD807409
    Consensus CDS
    CCDS52175.1
    UniProtKB/TrEMBL
    Q7TMN8
    Related
    ENSMUST00000145952.2
    Conserved Domains (3) summary
    COG5048
    Location:23462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:519544
    zf-H2C2_2; Zinc-finger double domain
  3. NM_172740.2NP_766328.2  zinc finger protein 420

    See identical proteins and their annotated locations for NP_766328.2

    Status: VALIDATED

    Source sequence(s)
    AC149283
    Consensus CDS
    CCDS52175.1
    UniProtKB/TrEMBL
    Q7TMN8
    Related
    ENSMUSP00000074417.7, ENSMUST00000074876.13
    Conserved Domains (3) summary
    COG5048
    Location:23462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:519544
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29559392..29576727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250536.2XP_011248838.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011248838.1

    UniProtKB/TrEMBL
    Q7TMN8
    Conserved Domains (3) summary
    COG5048
    Location:23462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:519544
    zf-H2C2_2; Zinc-finger double domain
  2. XM_036152954.1XP_036008847.1  zinc finger protein 420 isoform X2

  3. XM_036152956.1XP_036008849.1  zinc finger protein 420 isoform X2

  4. XM_036152955.1XP_036008848.1  zinc finger protein 420 isoform X2

  5. XM_036152953.1XP_036008846.1  zinc finger protein 420 isoform X2

  6. XM_011250538.1XP_011248840.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011248840.1

    UniProtKB/TrEMBL
    Q7TMN8
    Conserved Domains (3) summary
    COG5048
    Location:23462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:283303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:519544
    zf-H2C2_2; Zinc-finger double domain