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    FMO5 flavin containing monooxygenase 5 [ Homo sapiens (human) ]

    Gene ID: 2330, updated on 15-Mar-2013
    Official Symbol
    FMO5provided by HGNC
    Official Full Name
    flavin containing monooxygenase 5provided by HGNC
    Primary source
    HGNC:3773
    Locus tag
    RP11-337C18.2
    See related
    Ensembl:ENSG00000131781; HPRD:04904; MIM:603957; Vega:OTTHUMG00000014607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
    Location :
    1q21.1
    Sequence :
    Chromosome: 1; NC_000001.10 (146655884..146697230, complement)
    See FMO5 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505794 Neighboring gene protein disulfide isomerase family A, member 3 pseudogene Neighboring gene chaperonin containing TCP1, subunit 8 (theta) pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene prostaglandin reductase 1 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. Ross CJ, et al. Nat Genet, 2009 Dec. PMID 19898482.
    3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. Wheeler HE, et al. PLoS Genet, 2009 Oct. PMID 19834535.
    4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.
    3. fmo5 displayed a significant, dominant liver-specific mRNA profile.
      Title: Quantitative analysis of FMO gene mRNA levels in human tissues.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N,N-dimethylaniline monooxygenase activity NAS
    Non-traceable Author Statement
    more info
    		  
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle NAS
    Non-traceable Author Statement
    more info
    		  
    intrinsic to endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 5
    Names
    dimethylaniline monooxygenase [N-oxide-forming] 5
    FMO 5
    dimethylaniline oxidase 5
    hepatic flavin-containing monooxygenase 5
    NP_001138301.1
    NP_001138302.1
    NP_001452.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144829.1 → NP_001138301.1  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and contains an alternate exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2) and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK225739, AL356378, DA354058, DB230162
      Consensus CDS
      CCDS44209.1
      UniProtKB/Swiss-Prot
      P49326
      Related
      ENSP00000416011, OTTHUMP00000231954, ENST00000441068, OTTHUMT00000387965
      Conserved Domains (1) summary
      pfam13738
      Location:24 – 221
      Blast Score: 138
      Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

    2. NM_001144830.1 → NP_001138302.1  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK022172, AL356378, BC035687, Z47553
      Consensus CDS
      CCDS44210.1
      UniProtKB/Swiss-Prot
      P49326
      UniProtKB/TrEMBL
      Q9HA79
      Related
      ENSP00000358277, OTTHUMP00000016307, ENST00000369272, OTTHUMT00000040376
      Conserved Domains (1) summary
      pfam13738
      Location:24 – 221
      Blast Score: 137
      Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

    3. NM_001461.2 → NP_001452.2  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK222728, AL356378, DA354058, DB230162, Z47553
      Consensus CDS
      CCDS926.1
      UniProtKB/Swiss-Prot
      P49326
      UniProtKB/TrEMBL
      Q53H53
      Related
      ENSP00000254090, OTTHUMP00000016306, ENST00000254090, OTTHUMT00000040373
      Conserved Domains (1) summary
      pfam00743
      Location:3 – 520
      Blast Score: 2364
      FMO-like; Flavin-binding monooxygenase-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_003871055.2 Reference GRCh37.p10 PATCHES

      Range
      3924810..3966143, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      146655884..146697230, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      120068389..120109734, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      153657762..153699095, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01004398.1 (92553..133898) None
    genomic AC241584.3 (194267..200298) None
    genomic AC242426.1 (138539..173840) None
    genomic AL356378.17 CAH72648.1
      CAH72649.1
    genomic AMYH01001373.1 (1793716..1835049) None
    genomic AY902236.1 AAW69390.1
    genomic CH471223.1 EAW50939.1
      EAW50940.1
      EAW50941.1
      EAW50942.1
      EAW50943.1
    mRNA AK022172.1 BAB13975.1
    mRNA AK222728.1 BAD96448.1
    mRNA AK225739.1 None
    mRNA AK314647.1 BAG37208.1
    mRNA BC020872.1 None
    mRNA BC035687.1 AAH35687.1
    mRNA DA354058.1 None
    mRNA DB230162.1 None
    mRNA L37080.1 AAA67849.1
    mRNA Z47553.1 CAA87633.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49326.2 GenPept UniProtKB/Swiss-Prot:P49326

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
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        Link to related EST entry
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        Full text in PubMedCentral identified from shared sequence links
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        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
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        Link to Nucleotide RefSeq RNAs
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        Related SNP records
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      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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