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FMO5 flavin containing monooxygenase 5 [ Homo sapiens (human) ]

Gene ID: 2330, updated on 7-May-2016
Official Symbol
FMO5provided by HGNC
Official Full Name
flavin containing monooxygenase 5provided by HGNC
Primary source
HGNC:HGNC:3773
See related
Ensembl:ENSG00000131781 HPRD:04904; MIM:603957; Vega:OTTHUMG00000014607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
Orthologs
Location:
1q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (147184300..147225798, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146655884..146697390, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene protein disulfide isomerase family A member 3 pseudogene 1 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1 Neighboring gene ribosomal protein L7a pseudogene 15 Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene prostaglandin reductase 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N,N-dimethylaniline monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
drug metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dimethylaniline monooxygenase [N-oxide-forming] 5
Names
FMO 5
dimethylaniline oxidase 5
hepatic flavin-containing monooxygenase 5
NP_001138301.1
NP_001138302.1
NP_001452.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144829.2NP_001138301.1  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 2

    See identical proteins and their annotated locations for NP_001138301.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR and contains an alternate 3' terminal exon including coding region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK225739, DA354058
    Consensus CDS
    CCDS44209.1
    UniProtKB/Swiss-Prot
    P49326
    Related
    ENSP00000416011, OTTHUMP00000231954, ENST00000441068, OTTHUMT00000387965
    Conserved Domains (2) summary
    pfam00743
    Location:3426
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001144830.2NP_001138302.1  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 3

    See identical proteins and their annotated locations for NP_001138302.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    BC035687, DA354058
    Consensus CDS
    CCDS44210.1
    UniProtKB/Swiss-Prot
    P49326
    Related
    ENSP00000358277, OTTHUMP00000016307, ENST00000369272, OTTHUMT00000040376
    Conserved Domains (2) summary
    pfam00743
    Location:3279
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_001461.3NP_001452.2  dimethylaniline monooxygenase [N-oxide-forming] 5 isoform 1

    See identical proteins and their annotated locations for NP_001452.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK314647, BC035687, DA354058
    Consensus CDS
    CCDS926.1
    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Related
    ENSP00000254090, OTTHUMP00000016306, ENST00000254090, OTTHUMT00000040373
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    147184300..147225798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509353.1XP_011507655.1  

    See identical proteins and their annotated locations for XP_011507655.1

    UniProtKB/Swiss-Prot
    P49326
    Related
    ENSP00000462062, ENST00000578284
    Conserved Domains (2) summary
    pfam00743
    Location:3426
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. XM_005272947.3XP_005273004.1  

    See identical proteins and their annotated locations for XP_005273004.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. XM_011509350.1XP_011507652.1  

    See identical proteins and their annotated locations for XP_011507652.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  4. XM_006711245.2XP_006711308.1  

    See identical proteins and their annotated locations for XP_006711308.1

    UniProtKB/Swiss-Prot
    P49326
    Conserved Domains (2) summary
    pfam00743
    Location:3279
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  5. XM_005272948.3XP_005273005.1  

    See identical proteins and their annotated locations for XP_005273005.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  6. XM_005272946.3XP_005273003.1  

    See identical proteins and their annotated locations for XP_005273003.1

    UniProtKB/Swiss-Prot
    P49326
    UniProtKB/TrEMBL
    A0A024QYY6
    Conserved Domains (2) summary
    pfam00743
    Location:3532
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  7. XM_011509351.1XP_011507653.1  

    Conserved Domains (2) summary
    pfam00743
    Location:3469
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:843
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  8. XM_006711244.2XP_006711307.1  

    Conserved Domains (2) summary
    pfam00743
    Location:3282
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  9. XM_011509352.1XP_011507654.1  

    Conserved Domains (2) summary
    pfam00743
    Location:3276
    FMO-like; Flavin-binding monooxygenase-like
    pfam13450
    Location:868
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    148552431..148593764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)