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MGRN1 mahogunin ring finger 1 [ Homo sapiens (human) ]

Gene ID: 23295, updated on 26-May-2016
Official Symbol
MGRN1provided by HGNC
Official Full Name
mahogunin ring finger 1provided by HGNC
Primary source
HGNC:HGNC:20254
See related
Ensembl:ENSG00000102858 HPRD:07397; MIM:607559; Vega:OTTHUMG00000176436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF156
Summary
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Orthologs
Location:
16p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (4616493..4690974)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4674825..4740975)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cell death-inducing p53 target 1 Neighboring gene chromosome 16 open reading frame 96 Neighboring gene UBA like domain containing 1 Neighboring gene microRNA 6769a Neighboring gene nudix hydrolase 16 like 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene chromosome 16 open reading frame 71

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of G-protein coupled receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase MGRN1
Names
RING finger protein 156
mahogunin RING finger protein 1
mahogunin ring finger 1, E3 ubiquitin protein ligase
mahogunin, ring finger 1
probable E3 ubiquitin-protein ligase MGRN1
NP_001135761.2
NP_001135762.1
NP_001135763.2
NP_056061.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142289.2NP_001135761.2  E3 ubiquitin-protein ligase MGRN1 isoform 2

    See identical proteins and their annotated locations for NP_001135761.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471397
    Consensus CDS
    CCDS59256.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000468819, OTTHUMP00000254321, ENST00000588994, OTTHUMT00000432061
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
  2. NM_001142290.2NP_001135762.1  E3 ubiquitin-protein ligase MGRN1 isoform 3

    See identical proteins and their annotated locations for NP_001135762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB011116, AC023830, DA590130
    Consensus CDS
    CCDS45402.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000382487, OTTHUMP00000254320, ENST00000399577, OTTHUMT00000432060
    Conserved Domains (2) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001142291.2NP_001135763.2  E3 ubiquitin-protein ligase MGRN1 isoform 4

    See identical proteins and their annotated locations for NP_001135763.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC023830, DA590130, EF471398
    Consensus CDS
    CCDS45401.2
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000393311, ENST00000415496
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
  4. NM_015246.3NP_056061.1  E3 ubiquitin-protein ligase MGRN1 isoform 1

    See identical proteins and their annotated locations for NP_056061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC023830, BC050389, DA590130
    Consensus CDS
    CCDS42115.1
    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000262370, OTTHUMP00000254319, ENST00000262370, OTTHUMT00000432059
    Conserved Domains (2) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. NR_102267.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023830, AK299052

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    4616493..4690974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522441.1XP_011520743.1  

    Conserved Domains (2) summary
    PHA02929
    Location:195294
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:240283
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_005255217.1XP_005255274.1  

    Conserved Domains (2) summary
    PHA02929
    Location:233332
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:278321
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_005255218.1XP_005255275.1  

    Conserved Domains (3) summary
    PHA02929
    Location:233332
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:278321
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:274450
    rad18; DNA repair protein rad18
  4. XM_005255219.3XP_005255276.1  

    Conserved Domains (2) summary
    PHA02929
    Location:233332
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:278321
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  5. XM_005255220.3XP_005255277.1  

    See identical proteins and their annotated locations for XP_005255277.1

    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000467414, OTTHUMP00000254318, ENST00000587747, OTTHUMT00000432058
    Conserved Domains (2) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  6. XM_005255221.3XP_005255278.1  

    See identical proteins and their annotated locations for XP_005255278.1

    UniProtKB/Swiss-Prot
    O60291
    Related
    ENSP00000465860, OTTHUMP00000254322, ENST00000586183, OTTHUMT00000432062
    Conserved Domains (3) summary
    PHA02929
    Location:232331
    PHA02929; N1R/p28-like protein; Provisional
    cd00162
    Location:277320
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    TIGR00599
    Location:273449
    rad18; DNA repair protein rad18
  7. XM_011522442.1XP_011520744.1  

    Conserved Domains (1) summary
    cd00162
    Location:4083
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_429639.1 RNA Sequence

    Related
    ENST00000536343, OTTHUMT00000432057

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    4674882..4741756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)