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ADGRL3 adhesion G protein-coupled receptor L3 [ Homo sapiens (human) ]

Gene ID: 23284, updated on 8-May-2016
Official Symbol
ADGRL3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor L3provided by HGNC
Primary source
HGNC:HGNC:20974
See related
Ensembl:ENSG00000150471 HPRD:10055; MIM:616417; Vega:OTTHUMG00000160690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CL3; LEC3; CIRL3; LPHN3
Summary
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4q13.1
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (61383124..62078335)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (62066949..62938168)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377249 Neighboring gene ribosomal protein L17 pseudogene 19 Neighboring gene uncharacterized LOC105377250 Neighboring gene ribosomal protein S12 pseudogene 9 Neighboring gene adhesion G protein-coupled receptor L3 antisense RNA 1 Neighboring gene uncharacterized LOC101927145 Neighboring gene ribosomal protein S15a pseudogene 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
NHGRI GWA Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
adhesion G protein-coupled receptor L3
Names
CIRL-3
calcium-independent alpha-latrotoxin receptor 3
latrophilin homolog 3 (cow)
latrophilin-3
lectomedin 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033950.2 RefSeqGene

    Range
    5001..882080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322246.1NP_001309175.1  adhesion G protein-coupled receptor L3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the 5' region and contains a novel exon in the 3' coding region; the latter causes a frameshift compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment in the 5' region and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB018311, AC007511, AC092643, AF307080, AK309793, BF511741, DA808156
    Conserved Domains (7) summary
    smart00284
    Location:137393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495559
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8741119
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:43123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11391203
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:559789
    DUF3497; Domain of unknown function (DUF3497)
  2. NM_001322402.1NP_001309331.1  adhesion G protein-coupled receptor L3 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007511, AC092643, AF307080, AK294689, AK309793, BF511741, DA808156
    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12071537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)
  3. NM_015236.5NP_056051.2  adhesion G protein-coupled receptor L3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056051.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 5' region compared to variant 1. The resulting isoform (2) is shorter missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB018311, AC007511, AC092643, AC092663, AC108161, AF307080, AK309793, BF511741
    Consensus CDS
    CCDS54768.1
    UniProtKB/Swiss-Prot
    Q9HAR2
    Related
    ENSP00000422533, OTTHUMP00000218742, ENST00000514591, OTTHUMT00000361765
    Conserved Domains (7) summary
    smart00284
    Location:137393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495559
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8741119
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:43123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11391469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:559789
    DUF3497; Domain of unknown function (DUF3497)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    61383124..62078335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531788.1XP_011530090.1  

    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12071543
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)
  2. XM_011531789.1XP_011530091.1  

    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12071537
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)
  3. XM_011531786.1XP_011530088.1  

    UniProtKB/TrEMBL
    E7ETE3
    Related
    ENSP00000425884, OTTHUMP00000218747, ENST00000506746, OTTHUMT00000361771
    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421178
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11981571
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)
  4. XM_011531790.1XP_011530092.1  

    UniProtKB/TrEMBL
    E7EVD6
    Related
    ENSP00000421372, OTTHUMP00000218754, ENST00000507625, OTTHUMT00000361778
    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421178
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11981528
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)
  5. XM_011531787.1XP_011530089.1  

    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9291174
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11941567
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627844
    DUF3497; Domain of unknown function (DUF3497)
  6. XM_011531791.1XP_011530093.1  

    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:869921
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11851515
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627844
    DUF3497; Domain of unknown function (DUF3497)
  7. XM_011531785.1XP_011530087.1  

    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:877929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558622
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9371182
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12021575
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:622852
    DUF3497; Domain of unknown function (DUF3497)
  8. XM_011531784.1XP_011530086.1  

    Conserved Domains (7) summary
    smart00284
    Location:200456
    OLF; Olfactomedin-like domains
    smart00303
    Location:877929
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:558622
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9371182
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12021575
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:622852
    DUF3497; Domain of unknown function (DUF3497)
  9. XM_011531792.1XP_011530094.1  

    UniProtKB/Swiss-Prot
    Q9HAR2
    Related
    ENSP00000423388, OTTHUMP00000218740, ENST00000512091, OTTHUMT00000361763
    Conserved Domains (7) summary
    smart00284
    Location:137393
    OLF; Olfactomedin-like domains
    smart00303
    Location:814866
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:495559
    HormR; Domain present in hormone receptors
    pfam00002
    Location:8741119
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:43123
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:11391469
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:559789
    DUF3497; Domain of unknown function (DUF3497)
  10. XM_011531793.1XP_011530095.1  

    UniProtKB/TrEMBL
    E7EUP0
    Related
    ENSP00000423787, OTTHUMP00000218751, ENST00000509896, OTTHUMT00000361775
    Conserved Domains (7) summary
    smart00284
    Location:205461
    OLF; Olfactomedin-like domains
    smart00303
    Location:882934
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:563627
    HormR; Domain present in hormone receptors
    pfam00002
    Location:9421187
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:12071271
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam12003
    Location:627857
    DUF3497; Domain of unknown function (DUF3497)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    62398708..62974117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)