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FLT3LG fms related tyrosine kinase 3 ligand [ Homo sapiens (human) ]

Gene ID: 2323, updated on 8-May-2016
Official Symbol
FLT3LGprovided by HGNC
Official Full Name
fms related tyrosine kinase 3 ligandprovided by HGNC
Primary source
HGNC:HGNC:3766
See related
Ensembl:ENSG00000090554 HPRD:02477; MIM:600007; Vega:OTTHUMG00000186490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FL; FLT3L
Summary
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]
Orthologs
Location:
19q13.3
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (49474172..49486234)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49977455..49989491)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PIH1 domain containing 1 Neighboring gene aldehyde dehydrogenase 16 family member A1 Neighboring gene ribosomal protein L13a Neighboring gene small nucleolar RNA, C/D box 32A Neighboring gene small nucleolar RNA, C/D box 33

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
embryonic hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
lymphocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process in bone marrow IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation in bone marrow IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of myeloid dendritic cell activation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
intrinsic component of external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
fms-related tyrosine kinase 3 ligand
Names
flt3 ligand

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204502.1NP_001191431.1  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, BC144129, DB490139, U03858
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    P49771
    UniProtKB/TrEMBL
    B7ZLY4
    Related
    ENSP00000470453, OTTHUMP00000270987, ENST00000600429, OTTHUMT00000465303
    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  2. NM_001204503.1NP_001191432.1  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, U03858
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    P49771
    Related
    ENSP00000469613, OTTHUMP00000270989, ENST00000594009, OTTHUMT00000465305
    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  3. NM_001278637.1NP_001265566.1  fms-related tyrosine kinase 3 ligand isoform 2

    See identical proteins and their annotated locations for NP_001265566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC010619, BC011914, BC028001
    Consensus CDS
    CCDS62753.1
    UniProtKB/Swiss-Prot
    P49771
    Conserved Domains (1) summary
    pfam02947
    Location:177
    Flt3_lig; flt3 ligand
  4. NM_001278638.1NP_001265567.1  fms-related tyrosine kinase 3 ligand isoform 2

    See identical proteins and their annotated locations for NP_001265567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same isoform (2).
    Source sequence(s)
    AC010619, BC011914
    Consensus CDS
    CCDS62753.1
    UniProtKB/Swiss-Prot
    P49771
    Related
    ENSP00000204637, OTTHUMP00000270986, ENST00000204637, OTTHUMT00000465301
    Conserved Domains (1) summary
    pfam02947
    Location:177
    Flt3_lig; flt3 ligand
  5. NM_001459.3NP_001450.2  fms-related tyrosine kinase 3 ligand isoform 1 precursor

    See identical proteins and their annotated locations for NP_001450.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    BC006331, BC136464, DB490139
    Consensus CDS
    CCDS12767.1
    UniProtKB/Swiss-Prot
    P49771
    Related
    ENSP00000468977, OTTHUMP00000270984, ENST00000597551, OTTHUMT00000465299
    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    49474172..49486234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526675.1XP_011524977.1  

    See identical proteins and their annotated locations for XP_011524977.1

    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  2. XM_011526678.1XP_011524980.1  

    See identical proteins and their annotated locations for XP_011524980.1

    Conserved Domains (1) summary
    pfam02947
    Location:27141
    Flt3_lig; flt3 ligand
  3. XM_011526683.1XP_011524985.1  

    Conserved Domains (1) summary
    pfam02947
    Location:159
    Flt3_lig; flt3 ligand
  4. XM_011526676.1XP_011524978.1  

    See identical proteins and their annotated locations for XP_011524978.1

    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  5. XM_011526681.1XP_011524983.1  

    Conserved Domains (1) summary
    pfam02947
    Location:177
    Flt3_lig; flt3 ligand
  6. XM_011526682.1XP_011524984.1  

    See identical proteins and their annotated locations for XP_011524984.1

    UniProtKB/Swiss-Prot
    P49771
    Related
    ENSP00000471226, OTTHUMP00000270988, ENST00000595510, OTTHUMT00000465304
    Conserved Domains (1) summary
    pfam02947
    Location:177
    Flt3_lig; flt3 ligand
  7. XM_005258682.3XP_005258739.3  

    See identical proteins and their annotated locations for XP_005258739.3

    Conserved Domains (1) summary
    pfam02947
    Location:27119
    Flt3_lig; flt3 ligand
  8. XM_011526672.1XP_011524974.1  

    See identical proteins and their annotated locations for XP_011524974.1

    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  9. XM_005258681.3XP_005258738.3  

    See identical proteins and their annotated locations for XP_005258738.3

    UniProtKB/TrEMBL
    M0QYM9
    Related
    ENSP00000469942, OTTHUMP00000270983, ENST00000596435, OTTHUMT00000465298
    Conserved Domains (1) summary
    pfam02947
    Location:27141
    Flt3_lig; flt3 ligand
  10. XM_005258680.3XP_005258737.3  

    See identical proteins and their annotated locations for XP_005258737.3

    UniProtKB/TrEMBL
    M0QYM9
    Conserved Domains (1) summary
    pfam02947
    Location:27141
    Flt3_lig; flt3 ligand
  11. XM_011526674.1XP_011524976.1  

    See identical proteins and their annotated locations for XP_011524976.1

    Related
    ENSP00000469181, OTTHUMP00000270990, ENST00000598555, OTTHUMT00000465307
    Conserved Domains (1) summary
    pfam02947
    Location:27141
    Flt3_lig; flt3 ligand
  12. XM_005258683.3XP_005258740.3  

    Conserved Domains (1) summary
    pfam02947
    Location:27119
    Flt3_lig; flt3 ligand
  13. XM_011526673.1XP_011524975.1  

    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  14. XM_011526680.1XP_011524982.1  

    Conserved Domains (1) summary
    pfam02947
    Location:27114
    Flt3_lig; flt3 ligand
  15. XM_011526679.1XP_011524981.1  

    Conserved Domains (1) summary
    pfam02947
    Location:27119
    Flt3_lig; flt3 ligand
  16. XM_011526677.1XP_011524979.1  

    Conserved Domains (1) summary
    pfam02947
    Location:27159
    Flt3_lig; flt3 ligand
  17. XM_006723116.2XP_006723179.2  

    See identical proteins and their annotated locations for XP_006723179.2

    Conserved Domains (1) summary
    pfam02947
    Location:27119
    Flt3_lig; flt3 ligand

RNA

  1. XR_935782.1 RNA Sequence

  2. XR_935781.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    49978739..49990762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)