FLT3 fms-related tyrosine kinase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: FLT3provided by HGNC
Official Full Name: fms-related tyrosine kinase 3provided by HGNC
Primary source: HGNC:3765
Locus tag: RP11-153M24.3
See related: Ensembl:ENSG00000122025; HPRD:00635; MIM:136351; Vega:OTTHUMG00000016646
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLK2; STK1; CD135; FLK-2
Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 13q12

Sequence :: Chromosome: 13; NC_000013.10 (28577411..28674729, complement)

See FLT3 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Y654 of beta-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of beta-catenin
Title: Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin.
SGI-1776 preferentially target FLT3-ITD acute myeloid leukemia cells.
Title: The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells.
FLT3mut were associated with a significantly worse prognosis in normal karyotype acute myeloid leukemia patients with non-A-type NPM1mut.
Title: Clinical implications of non-A-type NPM1 and FLT3 mutations in patients with normal karyotype acute myeloid leukemia.
Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA.
Title: Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA.
FMS-like tyrosine kinase 3 internal tandem duplication is seen in the gene sequence of 207 Chinese patients with de novo acute myeloid leukemia.
Title: FMS-like tyrosine kinase 3 internal tandem duplication and the patterns of its gene sequence in 207 Chinese patients with de novo acute myeloid leukemia.
FLT3 internal tandem duplication is associated with response to therapy in adult acute myeloid leukemia.
Title: Minimal residual disease monitoring based on FLT3 internal tandem duplication in adult acute myeloid leukemia.
We conclude that FLT3 mutation is rare in T-ALL, and its presence supports T/myeloid lineage.
Title: CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia.
Data show that the presence of mutations of NPM1 and FLT3-ITD significantly decreased with age in adult acute myeloid leukemia.
Title: Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).
FLT3-TKD mutations are associated with FLT3-TKD mutations.
Title: Meta-analysis for the potential application of FLT3-TKD mutations as prognostic indicator in non-promyelocytic AML.
The acute myeloid leukemia children with FLT3/ITD mutations present a high peripheral WBC count and a high marrow blast percentage at diagnosis and have an unfavorable outcome.
Title: [FLT3 mutations in children with acute myeloid leukemia: a single center study].

Submit: New GeneRIF Correction See all (278)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_004110.1	NP_003736.1	SOCS1	BIND	PubMed	Socs1 interacts with Flt3. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Flt3.
P36888	Q13191	CBLB	HPRD	PubMed
P36888	Q96SL8	FIZ1	HPRD	PubMed
P36888	P36888	FLT3	HPRD	PubMed
P36888	P49771	FLT3LG	HPRD	PubMed
P36888	P62993	GRB2	HPRD	PubMed
P36888	O00145	INPP5D	HPRD	PubMed
P36888	P16333	NCK1	HPRD	PubMed
P36888	Q05209	PTPN12	HPRD	PubMed
P36888	P29350	PTPN6	HPRD	PubMed
P36888	P78314	SH3BP2	HPRD	PubMed
P36888	O15524	SOCS1	HPRD	PubMed
BioGRID:108610	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108610	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108610	BioGRID:114089	IKBKG	BioGRID	PubMed	Reconstituted Complex
BioGRID:108610	BioGRID:112372	SIAH1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108610	BioGRID:114203	SOCS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108610	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:108610	BioGRID:114672	UBE2L6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
cytokine receptor activity	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	TAS Traceable Author Statement more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
vascular endothelial growth factor-activated receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cellular response to cytokine stimulus	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
lymphocyte differentiation	IEA Inferred from Electronic Annotation more info
myeloid progenitor cell differentiation	TAS Traceable Author Statement more info	PubMed
negative regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine phosphorylation	TAS Traceable Author Statement more info	PubMed
positive regulation of MAP kinase activity	TAS Traceable Author Statement more info	PubMed
positive regulation of MAPK cascade	TAS Traceable Author Statement more info	PubMed
positive regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
positive regulation of phosphatidylinositol 3-kinase activity	TAS Traceable Author Statement more info	PubMed
positive regulation of phosphatidylinositol 3-kinase cascade	TAS Traceable Author Statement more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	TAS Traceable Author Statement more info	PubMed
pro-B cell differentiation	IEA Inferred from Electronic Annotation more info
pro-T cell differentiation	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
vascular endothelial growth factor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cell surface	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: receptor-type tyrosine-protein kinase FLT3

Names: receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III

NP_004110.2

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007066.1 RefSeqGene

Range

4977..102295

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004119.2 → NP_004110.2 receptor-type tyrosine-protein kinase FLT3

Status: REVIEWED

Source sequence(s)

AL356915, AL591024, AW057705, BI461248, U02687, Z26652

Consensus CDS

CCDS31953.1

UniProtKB/Swiss-Prot

P36888

Related

ENSP00000241453, OTTHUMP00000018181, ENST00000241453, OTTHUMT00000044319

Conserved Domains (2) summary

cl11960
Location:265 – 331
Blast Score: 107

Ig; Immunoglobulin domain

cl09925
Location:571 – 947
Blast Score: 1191

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

28577411..28674729, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

9398611..9496033, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL356915.19	CAI12447.1
genomic	AL445262.7	CAI17231.1
genomic	AL591024.14	CAH70634.1
genomic	CH471075.1	EAX08424.1
		EAX08425.1
genomic	U82002.1	AAB52916.1
mRNA	AW057705.1	None
mRNA	BC036028.1	None
mRNA	BC126350.1	AAI26351.1
mRNA	BC144039.1	AAI44040.1
mRNA	BC144040.1	AAI44041.1
mRNA	BI461248.1	None
mRNA	L36162.1	AAA35487.1
mRNA	U02687.1	AAA18947.1
mRNA	Z26652.1	CAA81393.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P36888.2	GenPept	UniProtKB/Swiss-Prot:P36888
Q5VTU6	GenPept	UniProtKB/TrEMBL:Q5VTU6
Q99815	GenPept	UniProtKB/TrEMBL:Q99815