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    ZC3H4 zinc finger CCCH-type containing 4 [ Homo sapiens (human) ]

    Gene ID: 23211, updated on 5-May-2013
    Official Symbol
    ZC3H4provided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 4provided by HGNC
    Primary source
    HGNC:17808
    See related
    Ensembl:ENSG00000130749; Vega:OTTHUMG00000183442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf7
    Summary
    This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]
    Location :
    19q13.32
    Sequence :
    Chromosome: 19; NC_000019.9 (47567444..47617009, complement)
    See ZC3H4 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene neuronal PAS domain protein 1 Neighboring gene transmembrane protein 160 Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene microRNA 3190 Neighboring gene microRNA 3191 Neighboring gene BCL2 binding component 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    2. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Speliotes EK, et al. Nat Genet, 2010 Nov. PMID 20935630.
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    4. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Matafora V, et al. Mol Cell Proteomics, 2009 Oct. PMID 19596686.
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:116818 BioGRID:107995 DBN1    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:108117 DYNC1H1    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:108606 FLNB    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:122271 MARC1    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:124037 MRPL45    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:120081 PAF1    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:111656 PSMA2    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:206343 Ppp1r10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116818 BioGRID:112290 SDHA    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:112366 SHMT1    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:107850 SLC25A10    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116818 BioGRID:121683 USP28    BioGRID  PubMed Co-fractionation 
    BioGRID:116818 BioGRID:121845 WIZ    BioGRID  PubMed Co-fractionation 

    Markers

    Genotypes

    Homology

    Clone Names

    • KIAA1064

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    zinc finger CCCH domain-containing protein 4
    Names
    zinc finger CCCH domain-containing protein 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027798.1 RefSeqGene

      Range
      5001..54566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015168.1 → NP_055983.1  zinc finger CCCH domain-containing protein 4

      Status: VALIDATED

      Source sequence(s)
      AB028987, AK074282, AK125279, AW603637, CN300565
      Consensus CDS
      CCDS42582.1
      UniProtKB/Swiss-Prot
      Q9UPT8
      Related
      ENSP00000253048, OTTHUMP00000271701, ENST00000253048, OTTHUMT00000466667
      Conserved Domains (1) summary
      smart00356
      Location:421 – 445
      Blast Score: 102
      ZnF_C3H1; zinc finger

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      47567444..47617009, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      43991640..44041061, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      47753345..47802909, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01041002.1 (5179..19916) None
    genomic ABBA01041003.1 None
    genomic AC008755.8 (91023..140576) None
    genomic AMYH01009876.1 (8369..57933) None
    mRNA AB028987.2 BAA83016.2
    mRNA AK074282.1 None
    mRNA AK125279.1 None
    mRNA AL050155.1 CAB43296.1
    mRNA AW603637.1 None
    mRNA CN300565.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UPT8.3 GenPept UniProtKB/Swiss-Prot:Q9UPT8

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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