Mat2a methionine adenosyltransferase II, alpha [Mus musculus] - Gene

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Summary

Official Symbol: Mat2aprovided by MGI
Official Full Name: methionine adenosyltransferase II, alphaprovided by MGI
Primary source: MGI:2443731
See related: Ensembl:ENSMUSG00000053907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MGC6545; D630045P18Rik

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Genomic context

Location :: 6 C1; 6

Sequence :: Chromosome: 6; NC_000072.6 (72432799..72439558, complement)

See Mat2a in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
Title: Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
MAT2A and MAT2beta genes are induced during hepatic stellate cell activation
Title: Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.
up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells.
Title: Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells.

Submit: New GeneRIF Correction

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
methionine adenosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
S-adenosylmethionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
circadian rhythm	ISO Inferred from Sequence Orthology more info
one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
response to cAMP	ISO Inferred from Sequence Orthology more info
response to drug	ISO Inferred from Sequence Orthology more info
response to hormone stimulus	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: S-adenosylmethionine synthase isoform type-2

Names: S-adenosylmethionine synthase isoform type-2; MAT 2; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; S-adenosylmethionine synthetase isoform type-2

NP_663544.1

EC 2.5.1.6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145569.4 → NP_663544.1 S-adenosylmethionine synthase isoform type-2

Status: PROVISIONAL

Source sequence(s)

AC116115

Consensus CDS

CCDS39515.1

UniProtKB/Swiss-Prot

Q3THS6

UniProtKB/TrEMBL

Q99J57

Related

ENSMUSP00000087118, ENSMUST00000059472

Conserved Domains (4) summary

pfam02773
Location:252 – 388
Blast Score: 654

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain

PTZ00104
Location:16 – 395
Blast Score: 1771

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:16 – 115
Blast Score: 507

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:128 – 250
Blast Score: 580

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38 C57BL/6J

Range

72432799..72439558, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

74527849..74534608, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC116115.11 (196885..203645)	None
mRNA	AB070266.1	BAD06937.1	DDY
mRNA	AK034757.1	BAC28823.1	C57BL/6J
mRNA	AK052764.1	BAC35139.1	C57BL/6J
mRNA	AK079420.1	BAC37642.1	C57BL/6J
mRNA	AK133960.1	BAE21955.1	C57BL/6J
mRNA	AK144189.1	BAE25756.1
mRNA	AK145407.1	BAE26420.1	C57BL/6J
mRNA	AK150040.1	BAE29262.1	C57BL/6J
mRNA	AK151281.1	BAE30267.1	C57BL/6J
mRNA	AK160869.1	None	C57BL/6J
mRNA	AK161852.1	BAE36605.1	C57BL/6J
mRNA	AK164137.1	BAE37643.1	C57BL/6J
mRNA	AK166671.1	BAE38932.1	C57BL/6J
mRNA	AK168155.1	BAE40120.1	DBA/2
mRNA	AK169705.1	BAE41317.1	NOD
mRNA	AK190931.1	None
mRNA	AK191201.1	None
mRNA	AK191379.1	None
mRNA	AK192240.1	None
mRNA	AK193673.1	None
mRNA	AK195580.1	None
mRNA	AK196280.1	None
mRNA	AK196623.1	None
mRNA	AK197103.1	None
mRNA	AK199984.1	None
mRNA	AK200511.1	None
mRNA	AK200816.1	None
mRNA	AK201922.1	None
mRNA	AK203805.1	None
mRNA	AK203913.1	None
mRNA	AK204874.1	None
mRNA	AK205713.1	None
mRNA	AK206552.1	None
mRNA	AK206774.1	None
mRNA	AK206845.1	None
mRNA	AK207182.1	None
mRNA	AK207616.1	None
mRNA	AK209257.1	None
mRNA	AK209535.1	None
mRNA	AK209635.1	None
mRNA	AK210321.1	None
mRNA	AK210811.1	None
mRNA	AK210966.1	None
mRNA	AK211573.1	None
mRNA	AK213373.1	None
mRNA	AK213948.1	None
mRNA	AK215611.1	None
mRNA	AK215700.1	None
mRNA	AK215987.1	None
mRNA	AK216312.1	None
mRNA	AK219100.1	None
mRNA	BC003451.1	AAH03451.1	FVB/N-3
mRNA	BC058360.1	AAH58360.1	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3TED1	GenPept	UniProtKB/TrEMBL:Q3TED1
Q3THS6.2	GenPept	UniProtKB/Swiss-Prot:Q3THS6
Q3TSS0	GenPept	UniProtKB/TrEMBL:Q3TSS0
Q3UAP7	GenPept	UniProtKB/TrEMBL:Q3UAP7
Q3UZA2	GenPept	UniProtKB/TrEMBL:Q3UZA2
Q6PE05	GenPept	UniProtKB/TrEMBL:Q6PE05
Q99J57	GenPept	UniProtKB/TrEMBL:Q99J57