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    PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 [ Homo sapiens ]

    Gene ID: 23207, updated on 11-May-2012
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    Summary

    Official Symbol
    PLEKHM2provided by HGNC
    Official Full Name
    pleckstrin homology domain containing, family M (with RUN domain) member 2provided by HGNC
    Primary source
    HGNC:29131
    See related
    Ensembl:ENSG00000116786; MIM:609613; Vega:OTTHUMG00000003062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKIP; KIAA0842; RP11-169K16.1
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    Genomic context

    Location :
    1p36.21
    Sequence :
    Chromosome: 1; NC_000001.10 (16010827..16061264)
    See PLEKHM2 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene CD24 molecule pseudogene 1 Neighboring gene DNA-damage inducible 1 homolog 2 (S. cerevisiae) Neighboring gene regulatory solute carrier protein, family 1, member 1 Neighboring gene solute carrier family 25, member 34 Neighboring gene transmembrane protein 82

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
    2. The intracellular fate of Salmonella depends on the recruitment of kinesin. Boucrot E, et al. Science, 2005 May 20. PMID 15905402.
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A dynamic process of kinesin recruitment in Salmonella-infected cells is down-regulated by the SifA-mediated recruitment of SKIP on membranes [SKIP]
      Title: The intracellular fate of Salmonella depends on the recruitment of kinesin.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BAA74865.1 NP_004512.1 KIF5B    BIND  PubMed SKIP interacts with kinesin HC. 
    BAA74865.1 NP_460194.1 sifA    BIND  PubMed SifA interacts with SKIP. This interaction was modeled on a demonstrated interaction between SifA from Salmonella typhimurium (strain HH215, strain PH011 and an unspecified strain) and human SKIP. 
    Pleckstrin homology domain containing, family M (with RUN domain) member 2 Q07866 KLC1    HPRD  PubMed  
    Pleckstrin homology domain containing, family M (with RUN domain) member 2 Q9NY26 SLC39A1    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    kinesin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    pleckstrin homology domain-containing family M member 2
    Names
    pleckstrin homology domain-containing family M member 2
    sifA and kinesin-interacting protein
    PH domain-containing family M member 2
    novel RUN and PH domain-containing protein
    salmonella-induced filaments A and kinesin-interacting protein
    SifA (Salmonella-induced filaments A) and kinesin-interacting protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015164.2 → NP_055979.2  pleckstrin homology domain-containing family M member 2

      Status: VALIDATED

      Source sequence(s)
      BC040441
      Consensus CDS
      CCDS44063.1
      UniProtKB/Swiss-Prot
      Q8IWE5
      Related
      ENSP00000364956, OTTHUMP00000003094, ENST00000375799, OTTHUMT00000008463
      Conserved Domains (2) summary
      cd00821
      Location:774 – 871
      Blast Score: 123
      PH; Pleckstrin homology (PH) domain
      cl02689
      Location:44 – 151
      Blast Score: 275
      RUN; RUN domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      16010827..16061264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      14530042..14580241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL121992.24 CAI22373.1
      CAI22374.1
    genomic AL450998.19 CAH70859.1
      CAH70860.1
    genomic AL606758.15 CAH72017.1
      CAH72018.1
    genomic CH471167.1 EAW51745.1
    mRNA AB020649.1 BAA74865.1
    mRNA AL137297.1 CAB70684.1
    mRNA BC008002.1 AAH08002.1
    mRNA BC016488.1 AAH16488.1
    mRNA BC030545.1 AAH30545.1
    mRNA BC040441.1 AAH40441.1
    mRNA BC042103.1 AAH42103.1
    mRNA BC068599.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IWE5.2 GenPept UniProtKB/Swiss-Prot:Q8IWE5
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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