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FAF2 Fas associated factor family member 2 [ Homo sapiens (human) ]

Gene ID: 23197, updated on 12-May-2016
Official Symbol
FAF2provided by HGNC
Official Full Name
Fas associated factor family member 2provided by HGNC
Primary source
HGNC:HGNC:24666
See related
Ensembl:ENSG00000113194 HPRD:16870; MIM:616935; Vega:OTTHUMG00000163228
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETEA; UBXD8; UBXN3B
Summary
The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]
Orthologs
Location:
5q35.2
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (176448306..176510074)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175875356..175937075)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor like GTPase 10 Neighboring gene HIG1 hypoxia inducible domain family member 2A Neighboring gene clathrin light chain B Neighboring gene ring finger protein 44 Neighboring gene cadherin related family member 2 Neighboring gene G protein regulated inducer of neurite outgrowth 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0887

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipase binding IDA
Inferred from Direct Assay
more info
PubMed 
lipase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER-associated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid particle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
VCP-NPL4-UFD1 AAA ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
lipid particle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
FAS-associated factor 2
Names
UBX domain containing 8
UBX domain protein 3B
UBX domain-containing protein 3B
UBX domain-containing protein 8
expressed in T-cells and eosinophils in atopic dermatitis

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014613.2NP_055428.1  FAS-associated factor 2

    See identical proteins and their annotated locations for NP_055428.1

    Status: REVIEWED

    Source sequence(s)
    AC010316, AL706430, BC014001
    Consensus CDS
    CCDS34296.1
    UniProtKB/Swiss-Prot
    Q96CS3
    Related
    ENSP00000261942, OTTHUMP00000223381, ENST00000261942, OTTHUMT00000372194
    Conserved Domains (3) summary
    cd02991
    Location:154269
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cd14414
    Location:1552
    UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
    cl00155
    Location:362442
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    176448306..176510074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534476.1XP_011532778.1  

    Conserved Domains (2) summary
    cd14414
    Location:1552
    UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
    cl00388
    Location:154220
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_011534475.1XP_011532777.1  

    Conserved Domains (3) summary
    cd02991
    Location:109224
    UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
    cl00155
    Location:317397
    UBQ; Ubiquitin-like proteins
    cl21463
    Location:1544
    UBA_like_SF; UBA domain-like superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    175308267..175369883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)