PASK PAS domain containing serine/threonine kinase [Homo sapiens] - Gene

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Summary

Official Symbol: PASKprovided by HGNC
Official Full Name: PAS domain containing serine/threonine kinaseprovided by HGNC
Primary source: HGNC:17270
See related: Ensembl:ENSG00000115687; HPRD:06328; MIM:607505; Vega:OTTHUMG00000133392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STK37; PASKIN; KIAA0135; DKFZp434O051; DKFZp686P2031
Summary: This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

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Genomic context

Location :: 2q37.3

Sequence :: Chromosome: 2; NC_000002.11 (242045515..242088878, complement)

See PASK in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion
Title: Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes.
Title: Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.
Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
Title: Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression.
Title: Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose.
identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails
Title: Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.
molecular cloning, gene expression, and comparison with mouse protein
Title: Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96RG2	Q96RG2	PASK	HPRD	PubMed
BioGRID:116790	BioGRID:108399	FBL	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116790	BioGRID:111662	PSMB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116790	BioGRID:114144	STK16	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116790	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116790	BioGRID:116272	WDR5	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
lipid binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol binding	IDA Inferred from Direct Assay more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
negative regulation of glycogen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of translation	TAS Traceable Author Statement more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
regulation of respiratory gaseous exchange	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: PAS domain-containing serine/threonine-protein kinase

Names: PAS domain-containing serine/threonine-protein kinase; per-arnt-sim (PAS) domain kinase

NP_055963.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252119.1 → NP_001239048.1 PAS domain-containing serine/threonine-protein kinase isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC063585, D50925, DA104684

UniProtKB/Swiss-Prot

Q96RG2

Conserved Domains (4) summary

cd00130
Location:133 – 232
Blast Score: 128

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd00180
Location:1005 – 1256
Blast Score: 438

PKc; Catalytic domain of Protein Kinases

smart00220
Location:999 – 1258
Blast Score: 607

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02459
Location:344 – 401
Blast Score: 92

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
NM_001252120.1 → NP_001239049.1 PAS domain-containing serine/threonine-protein kinase isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

AC005237, BC063585, CR749231

UniProtKB/Swiss-Prot

Q96RG2

Conserved Domains (4) summary

cd00130
Location:133 – 232
Blast Score: 128

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd00180
Location:1005 – 1249
Blast Score: 456

PKc; Catalytic domain of Protein Kinases

smart00220
Location:999 – 1251
Blast Score: 624

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02459
Location:344 – 401
Blast Score: 92

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
NM_001252122.1 → NP_001239051.1 PAS domain-containing serine/threonine-protein kinase isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two alternate splice sites in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK302417, BC063585, DA104684

UniProtKB/TrEMBL

B7Z7R6

UniProtKB/Swiss-Prot

Q96RG2

Conserved Domains (4) summary

cd00130
Location:133 – 232
Blast Score: 128

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd00180
Location:970 – 1214
Blast Score: 456

PKc; Catalytic domain of Protein Kinases

smart00220
Location:964 – 1216
Blast Score: 625

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02459
Location:309 – 366
Blast Score: 92

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
NM_001252124.1 → NP_001239053.1 PAS domain-containing serine/threonine-protein kinase isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks a splice site in the 3' coding region, which results in a frameshift and alternate 3' UTR compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL117400, BC050565, BC063585, DA104684

UniProtKB/TrEMBL

G5E9F1

UniProtKB/TrEMBL

Q05BE4

UniProtKB/Swiss-Prot

Q96RG2

Conserved Domains (3) summary

cd00130
Location:133 – 232
Blast Score: 128

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cl02459
Location:344 – 401
Blast Score: 92

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cl09925
Location:1005 – 1112
Blast Score: 171

PKc_like; Protein Kinases, catalytic domain
NM_015148.3 → NP_055963.2 PAS domain-containing serine/threonine-protein kinase isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which is shorter than isoform 1.

Source sequence(s)

BC063585, DA104684

Consensus CDS

CCDS2545.1

UniProtKB/Swiss-Prot

Q96RG2

Related

ENSP00000234040, OTTHUMP00000164573, ENST00000234040, OTTHUMT00000257246

Conserved Domains (4) summary

cd00130
Location:133 – 232
Blast Score: 128

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd00180
Location:1005 – 1249
Blast Score: 456

PKc; Catalytic domain of Protein Kinases

smart00220
Location:999 – 1251
Blast Score: 624

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02459
Location:344 – 401
Blast Score: 92

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

242045515..242088878, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

233801522..233845320, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005237.2 (74065..117428)	None
genomic	AF067137.1	AAC23506.1
genomic	CH471063.1	EAW71236.1
		EAW71237.1
		EAW71238.1
		EAW71239.1
		EAW71240.1
		EAW71241.1
		EAW71242.1
mRNA	AF387103.1	AAK69752.1
mRNA	AK026769.1	None
mRNA	AK056516.1	None
mRNA	AK296945.1	BAH12460.1
mRNA	AK302417.1	BAH13702.1
mRNA	AK302561.1	BAH13743.1
mRNA	AL117400.1	CAB55901.2
mRNA	BC020054.1	None
mRNA	BC043495.1	AAH43495.1
mRNA	BC050565.1	AAH50565.1
mRNA	BC063585.1	AAH63585.1
mRNA	CR749231.1	CAH18087.1
mRNA	D50925.2	BAA09484.2
mRNA	DA104684.1	None
mRNA	U79240.1	AAB50198.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q05BE4	GenPept	UniProtKB/TrEMBL:Q05BE4
Q14148	GenPept	UniProtKB/TrEMBL:Q14148
Q96RG2.3	GenPept	UniProtKB/Swiss-Prot:Q96RG2