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MPRIP myosin phosphatase Rho interacting protein [ Homo sapiens (human) ]

Gene ID: 23164, updated on 26-May-2016
Official Symbol
MPRIPprovided by HGNC
Official Full Name
myosin phosphatase Rho interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30321
See related
Ensembl:ENSG00000133030 HPRD:17591; MIM:612935; Vega:OTTHUMG00000059276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRIP; RIP3; M-RIP; RHOIP3; p116Rip
Orthologs
Location:
17p11.2
Exon count:
25
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (17042468..17192648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (16945790..17095962)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371562 Neighboring gene uncharacterized LOC105371563 Neighboring gene phospholipase D family member 6 Neighboring gene folliculin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
myosin phosphatase Rho-interacting protein
Names
Rho interacting protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015134.3NP_055949.2  myosin phosphatase Rho-interacting protein isoform 1

    See identical proteins and their annotated locations for NP_055949.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB189741, AC055811, AK092287, BE048871
    Consensus CDS
    CCDS42268.1
    UniProtKB/Swiss-Prot
    Q6WCQ1
    UniProtKB/TrEMBL
    Q8N236
    Related
    ENSP00000379156, OTTHUMP00000065508, ENST00000395811, OTTHUMT00000131586
    Conserved Domains (4) summary
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:738980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21478
    Location:708813
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  2. NM_201274.3NP_958431.2  myosin phosphatase Rho-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_958431.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC055811, AC079111, AY296247, BC075847, BE048871
    Consensus CDS
    CCDS32578.1
    UniProtKB/Swiss-Prot
    Q6WCQ1
    Related
    ENSP00000342379, OTTHUMP00000065509, ENST00000341712, OTTHUMT00000131587
    Conserved Domains (4) summary
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:390491
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:738980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21478
    Location:708813
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    17042468..17192648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523765.1XP_011522067.1  

    Conserved Domains (6) summary
    pfam04012
    Location:9181121
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:21572314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_011523762.1XP_011522064.1  

    Conserved Domains (6) summary
    pfam04012
    Location:9181121
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:21492232
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  3. XM_011523764.1XP_011522066.1  

    Conserved Domains (6) summary
    pfam04012
    Location:9181121
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:21572314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_011523763.1XP_011522065.1  

    Conserved Domains (6) summary
    pfam04012
    Location:8801083
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:10241152
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:502603
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl12013
    Location:8901079
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:21112194
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  5. XM_011523761.1XP_011522063.1  

    Conserved Domains (6) summary
    pfam04012
    Location:9181121
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:10621190
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:540641
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl12013
    Location:9281117
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:21492232
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  6. XM_005256563.3XP_005256620.1  

    Conserved Domains (6) summary
    pfam04012
    Location:8001003
    PspA_IM30; PspA/IM30 family
    pfam10473
    Location:9441072
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    cd01236
    Location:48183
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:422523
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl12013
    Location:828999
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl21478
    Location:20312114
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  7. XM_011523767.1XP_011522069.1  

    Conserved Domains (5) summary
    pfam07926
    Location:865987
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:508609
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:8561098
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21478
    Location:826931
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  8. XM_011523766.1XP_011522068.1  

    Conserved Domains (5) summary
    pfam07926
    Location:865987
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:508609
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:8561098
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21478
    Location:826931
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
  9. XM_005256564.3XP_005256621.2  

    See identical proteins and their annotated locations for XP_005256621.2

    UniProtKB/Swiss-Prot
    Q6WCQ1
    Related
    ENSP00000462688, OTTHUMP00000260866, ENST00000584067, OTTHUMT00000445175
    Conserved Domains (4) summary
    cd01236
    Location:16151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:352453
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    cl02488
    Location:700942
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21478
    Location:670775
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    16955735..17105592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)