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MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 23162, updated on 8-May-2016
Official Symbol
MAPK8IP3provided by HGNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:6884
See related
Ensembl:ENSG00000138834 HPRD:12014; MIM:605431; Vega:OTTHUMG00000128637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
syd; JIP3; SYD2; JIP-3; JSAP1
Summary
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16p13.3
Exon count:
34
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (1706183..1770317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1756184..1820318)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene cramped chromatin regulator homolog 1 Neighboring gene hematological and neurological expressed 1-like Neighboring gene uncharacterized LOC101929480 Neighboring gene microRNA 3177 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ00027, KIAA1066, DKFZp762N1113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
 
MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mitogen-activated protein kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
receptor signaling complex scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
lung alveolus development IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
axolemma IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C-Jun-amino-terminal kinase-interacting protein 3
Names
C-jun-amino-terminal kinase interacting protein 3
JNK MAP kinase scaffold protein 3
JNK-interacting protein 3
JNK/SAPK-associated protein-1
JNK/stress-activated protein kinase-associated protein 1
homolog of Drosophila Sunday driver 2
mitogen-activated protein kinase 8-interacting protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040439.1NP_001035529.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB028989, AC012180, BC087861, BM791368, BY795428, CA776361, CN361410, CN405914, CN405915
    Consensus CDS
    CCDS45379.1
    UniProtKB/Swiss-Prot
    Q9UPT6
    UniProtKB/TrEMBL
    E9PFH7
    Related
    ENSP00000348290, OTTHUMP00000254803, ENST00000356010, OTTHUMT00000433168
    Conserved Domains (4) summary
    pfam05887
    Location:843965
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    cl12013
    Location:381485
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_001318852.1NP_001305781.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1 by a single amino acid.
    Source sequence(s)
    AC012180, AI291346, BC144486, BC150266, BQ706804, DA135446
    UniProtKB/Swiss-Prot
    Q9UPT6
    UniProtKB/TrEMBL
    A0A087WYG2, B7ZMF3
    Conserved Domains (3) summary
    pfam05887
    Location:850972
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
  3. NM_015133.4NP_055948.2  C-Jun-amino-terminal kinase-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055948.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012180, AI291346, BC137124, BQ706804, DA135446
    Consensus CDS
    CCDS10442.2
    UniProtKB/Swiss-Prot
    Q9UPT6
    Related
    ENSP00000250894, OTTHUMP00000158803, ENST00000250894, OTTHUMT00000250508
    Conserved Domains (3) summary
    pfam05887
    Location:849971
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    1706183..1770317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522429.1XP_011520731.1  

    Conserved Domains (3) summary
    pfam05887
    Location:858980
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
  2. XM_011522431.1XP_011520733.1  

    Conserved Domains (4) summary
    pfam05887
    Location:849971
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    cl09111
    Location:455550
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. XM_011522430.1XP_011520732.1  

    Conserved Domains (4) summary
    pfam05887
    Location:852974
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    cl12013
    Location:390494
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_011522432.1XP_011520734.1  

    Conserved Domains (5) summary
    pfam05887
    Location:843965
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    cl09111
    Location:449544
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl12013
    Location:390494
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_005255187.1XP_005255244.1  

    Related
    ENSP00000481780, ENST00000610761
    Conserved Domains (3) summary
    pfam05887
    Location:850972
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
  6. XM_005255190.1XP_005255247.1  

    Conserved Domains (5) summary
    pfam05887
    Location:835957
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
    pfam07926
    Location:62167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:29186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    cl09111
    Location:441536
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    cl12013
    Location:382486
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_006720869.1XP_006720932.1  

    Conserved Domains (1) summary
    pfam05887
    Location:596718
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)
  8. XM_011522433.1XP_011520735.1  

    Conserved Domains (1) summary
    pfam05887
    Location:690812
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    1756194..1820266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)