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    FLI1 Friend leukemia virus integration 1 [ Homo sapiens ]

    Gene ID: 2313, updated on 13-May-2012

    Summary

    Official Symbol
    FLI1provided by HGNC
    Official Full Name
    Friend leukemia virus integration 1provided by HGNC
    Primary source
    HGNC:3749
    See related
    Ensembl:ENSG00000151702; HPRD:01901; MIM:193067; Vega:OTTHUMG00000165792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EWSR2; SIC-1

    Genomic context

    Location :
    11q24.1-q24.3
    Sequence :
    Chromosome: 11; NC_000011.9 (128563811..128683162)
    See FLI1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 7 pseudogene Neighboring gene v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) Neighboring gene uncharacterized LOC100507392 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene chromosome 11 open reading frame 45 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002008.2 NC_000007.11 STYXL1    BIND  PubMed FLI1 (EWS-FLI1) interacts with the DUSP24 gene (MK-STYX gene). 
    NP_002008.2 NP_057698.2 TDP2    BIND  PubMed FLI1 interacts with EAPII. 
    NP_002008.2 AY675319.1 TGFBR2    BIND  PubMed FLI1 (EWS-FLI1) interacts with the TGFBR2 promoter. 
    Q01543 P11308 ERG    HPRD  PubMed  
    Q01543 P41212 ETV6    HPRD  PubMed  
    Q01543 Q01844 EWSR1    HPRD  PubMed  
    Q01543 P15976 GATA1    HPRD  PubMed  
    Q01543 Q13351 KLF1    HPRD  PubMed  
    Q01543 O15198 SMAD9    HPRD  PubMed  
    Q01543 P11831 SRF    HPRD  PubMed  
    Q01543 O95551 TDP2    HPRD  PubMed  
    BioGRID:108602 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:108317 ELK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:108421 ETV6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108602 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108602 BioGRID:115904 KLF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108602 BioGRID:110263 SMAD3    BioGRID  PubMed Two-hybrid 
    BioGRID:108602 BioGRID:112600 SRF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    hemostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Friend leukemia integration 1 transcription factor
    Names
    Friend leukemia integration 1 transcription factor
    proto-oncogene Fli-1
    transcription factor ERGB

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167681.2NP_001161153.1  Friend leukemia integration 1 transcription factor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI354789, AK300153, AP001122, DC381599
      Consensus CDS
      CCDS53725.1
      UniProtKB/TrEMBL
      B4DTC6
      UniProtKB/TrEMBL
      G3V183
      Related
      ENSP00000432950, OTTHUMP00000230981, ENST00000534087, OTTHUMT00000386228
      Conserved Domains (2) summary
      cd08541
      Location:81171
      Blast Score: 471
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      cl02599
      Location:247330
      Blast Score: 425
      Ets; Ets-domain
    2. NM_002017.3NP_002008.2  Friend leukemia integration 1 transcription factor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI354789, AK313370, AP001122, DC381599
      Consensus CDS
      CCDS44768.1
      UniProtKB/Swiss-Prot
      Q01543
      Related
      ENSP00000399985, OTTHUMP00000230979, ENST00000429175, OTTHUMT00000386226
      Conserved Domains (2) summary
      cd08541
      Location:114204
      Blast Score: 474
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      cl02599
      Location:280363
      Blast Score: 428
      Ets; Ets-domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      128563811..128683162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      124512130..124631960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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