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    FLI1 Friend leukemia virus integration 1 [ Homo sapiens ]

    Gene ID: 2313, updated on 13-May-2012
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    Summary

    Official Symbol
    FLI1provided by HGNC
    Official Full Name
    Friend leukemia virus integration 1provided by HGNC
    Primary source
    HGNC:3749
    See related
    Ensembl:ENSG00000151702; HPRD:01901; MIM:193067; Vega:OTTHUMG00000165792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EWSR2; SIC-1
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    Genomic context

    Location :
    11q24.1-q24.3
    Sequence :
    Chromosome: 11; NC_000011.9 (128563811..128683162)
    See FLI1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 7 pseudogene Neighboring gene v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) Neighboring gene uncharacterized LOC100507392 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene chromosome 11 open reading frame 45 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma. Rosado FG, et al. Arch Pathol Lab Med, 2012 Mar. PMID 22372906.
    2. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. Okada Y, et al. PLoS One, 2011. PMID 21931859.
    3. Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia. Kornblau SM, et al. Blood, 2011 Nov 17. PMID 21917756.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs. McKinsey EL, et al. Oncogene, 2011 Dec 8. PMID 21643012.

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show there are no differences in the distribution of immunohistochemical reactivity for CD31, CD34, D2-40, or FLI1 between AIDS-related and non-AIDS-related Kaposi sarcoma (KS) or between nodular- and patch/plaque-stage KS.
      Title: Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma.
    2. Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells.
      Title: Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.
    3. we have demonstrated association between FLI1 and susceptibility to CL caused by L. braziliensis.
      Title: FLI1 polymorphism affects susceptibility to cutaneous leishmaniasis in Brazil.
    4. These results demonstrate that EWS-FLI blocks the ability of Runx2 to induce osteoblast specification of a mesenchymal progenitor cell.
      Title: The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation.
    5. a novel oncogenic mechanism in Ewing sarcoma, involving post-transcriptional derepression of IGF signaling by the EWS/Fli1 fusion oncoprotein via miRs
      Title: A novel oncogenic mechanism in Ewing sarcoma involving IGF pathway targeting by EWS/Fli1-regulated microRNAs.
    6. FLI1 expression is frequently abnormal and prognostically adverse in acute myeloid leukemia.
      Title: Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia.
    7. a role of Fli1 as a negative regulator of the estrogen receptor alpha gene in dermal fibroblasts.
      Title: Fli1 is a negative regulator of estrogen receptor α in dermal fibroblasts.
    8. these results demonstrate that in SSc fibroblasts, c-Abl is an upstream regulator of the profibrotic PKCdelta/phospho-Fli-1 pathway, via induction of PKCdelta nuclear localization.
      Title: The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts.
    9. The genome-wide binding sites for the FLI1 in primary human megakaryocytes to identify the essential regulator of complex mammalian differentiation processes.
      Title: Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.
    10. study demonstrates that a GA(n) microsatellite in the human Fli1 promoter is highly polymorphic
      Title: A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis.
    Submit: New GeneRIF Correction See all (49)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002008.2 NC_000007.11 STYXL1    BIND  PubMed FLI1 (EWS-FLI1) interacts with the DUSP24 gene (MK-STYX gene). 
    NP_002008.2 NP_057698.2 TDP2    BIND  PubMed FLI1 interacts with EAPII. 
    NP_002008.2 AY675319.1 TGFBR2    BIND  PubMed FLI1 (EWS-FLI1) interacts with the TGFBR2 promoter. 
    Q01543 P11308 ERG    HPRD  PubMed  
    Q01543 P41212 ETV6    HPRD  PubMed  
    Q01543 Q01844 EWSR1    HPRD  PubMed  
    Q01543 P15976 GATA1    HPRD  PubMed  
    Q01543 Q13351 KLF1    HPRD  PubMed  
    Q01543 O15198 SMAD9    HPRD  PubMed  
    Q01543 P11831 SRF    HPRD  PubMed  
    Q01543 O95551 TDP2    HPRD  PubMed  
    BioGRID:108602 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:108317 ELK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:108421 ETV6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108602 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108602 BioGRID:115904 KLF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108602 BioGRID:110263 SMAD3    BioGRID  PubMed Two-hybrid 
    BioGRID:108602 BioGRID:112600 SRF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108602 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    hemostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    Friend leukemia integration 1 transcription factor
    Names
    Friend leukemia integration 1 transcription factor
    proto-oncogene Fli-1
    transcription factor ERGB
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167681.2 → NP_001161153.1  Friend leukemia integration 1 transcription factor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI354789, AK300153, AP001122, DC381599
      Consensus CDS
      CCDS53725.1
      UniProtKB/TrEMBL
      B4DTC6
      UniProtKB/TrEMBL
      G3V183
      Related
      ENSP00000432950, OTTHUMP00000230981, ENST00000534087, OTTHUMT00000386228
      Conserved Domains (2) summary
      cd08541
      Location:81 – 171
      Blast Score: 471
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      cl02599
      Location:247 – 330
      Blast Score: 425
      Ets; Ets-domain

    2. NM_002017.3 → NP_002008.2  Friend leukemia integration 1 transcription factor isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI354789, AK313370, AP001122, DC381599
      Consensus CDS
      CCDS44768.1
      UniProtKB/Swiss-Prot
      Q01543
      Related
      ENSP00000399985, OTTHUMP00000230979, ENST00000429175, OTTHUMT00000386226
      Conserved Domains (2) summary
      cd08541
      Location:114 – 204
      Blast Score: 474
      SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
      cl02599
      Location:280 – 363
      Blast Score: 428
      Ets; Ets-domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      128563811..128683162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      124512130..124631960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB012624.1 BAA32805.1
    genomic AB012625.1 BAA32806.1
    genomic AF275879.1 AAA76854.1
      AAG33027.1
    genomic AP001122.5 (45558..164295) None
    genomic CH471065.1 EAW67715.1
      EAW67716.1
      EAW67717.1
      EAW67718.1
      EAW67719.1
      EAW67720.1
    genomic D38408.1 BAA07463.1
    genomic Y17293.1 CAA76731.1
    mRNA AF147318.1 None
    mRNA AI354789.1 None
    mRNA AK294279.1 BAG57565.1
    mRNA AK300153.1 BAG61938.1
    mRNA AK313370.1 BAG36169.1
    mRNA AY029368.1 AAK50443.1
    mRNA BC001670.1 AAH01670.1
    mRNA BC010115.1 AAH10115.1
    mRNA BX647094.1 None
    mRNA DC381599.1 None
    mRNA M93255.1 AAA58479.1
      AAA58480.1
    mRNA M98833.3 AAA35812.2
    mRNA S45205.1 AAB23637.1
    mRNA S64709.1 None
    mRNA X67001.1 CAA47399.1
    other-genetic DQ892582.2 ABM83508.1
    other-genetic DQ896858.2 ABM87857.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01543.1 GenPept UniProtKB/Swiss-Prot:Q01543
    Q9UEE2 GenPept UniProtKB/TrEMBL:Q9UEE2
    Q9UEE3 GenPept UniProtKB/TrEMBL:Q9UEE3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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