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FOXO3 forkhead box O3 [ Homo sapiens (human) ]

Gene ID: 2309, updated on 29-May-2016
Official Symbol
FOXO3provided by HGNC
Official Full Name
forkhead box O3provided by HGNC
Primary source
HGNC:HGNC:3821
See related
Ensembl:ENSG00000118689 HPRD:04061; MIM:602681; Vega:OTTHUMG00000015327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q21
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (108559823..108684769)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (108881026..109005972)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lactation elevated 1 Neighboring gene uncharacterized LOC105377932 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) pseudogene Neighboring gene uncharacterized LOC105377931 Neighboring gene SUMO2 pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 222 Neighboring gene zinc finger protein 259 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
NHGRI GWA Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of forkhead box O3 (FOXO3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat expression in Jurkat T cells increases the amount and the translocation of FOXO3a from the cytoplasm to the nucleus, indicating that FOXO3a is no longer phosphorylated PubMed
Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr HIV-1 Vpr inhibits insulin- and Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed

Go to the HIV-1, Human Interaction Database

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  • Endometrial cancer, organism-specific biosystem (from KEGG)
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  • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
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  • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
    Insulin Pathway, organism-specific biosystem
    Insulin Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
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  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
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  • PI-3K cascade:FGFR1, organism-specific biosystem (from REACTOME)
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  • PI-3K cascade:FGFR2, organism-specific biosystem (from REACTOME)
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  • PI-3K cascade:FGFR3, organism-specific biosystem (from REACTOME)
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  • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
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  • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
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  • Signal Transduction, organism-specific biosystem (from REACTOME)
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  • Signaling Pathways in Glioblastoma, organism-specific biosystem (from WikiPathways)
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  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
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  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
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  • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
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  • Signaling by NODAL, organism-specific biosystem (from REACTOME)
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  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
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  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
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  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
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  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
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  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
    Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
    Trk receptor signaling mediated by PI3K and PLC-gamma
  • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Validated targets of C-MYC transcriptional repression, organism-specific biosystem
    Validated targets of C-MYC transcriptional repression
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC12739, MGC31925, DKFZp781A0677

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
core promoter binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription cofactor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
antral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
initiation of primordial ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
forkhead box protein O3
Names
forkhead box O3A
forkhead homolog (rhabdomyosarcoma) like 1
forkhead in rhabdomyosarcoma-like 1
forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001455.3NP_001446.1  forkhead box protein O3

    See identical proteins and their annotated locations for NP_001446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' end and represents the longer transcript compared to variant 2. Both variants encode the same protein.
    Source sequence(s)
    AF032886, AK024103, AL096818, AL365509, CA389775
    Consensus CDS
    CCDS5068.1
    UniProtKB/Swiss-Prot
    O43524
    Related
    ENSP00000385824, ENST00000406360
    Conserved Domains (1) summary
    cd00059
    Location:157237
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. NM_201559.2NP_963853.1  forkhead box protein O3

    See identical proteins and their annotated locations for NP_963853.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK024103, AL096818, AL365509, BC020227, CD101760
    Consensus CDS
    CCDS5068.1
    UniProtKB/Swiss-Prot
    O43524
    Related
    ENSP00000339527, OTTHUMP00000016944, ENST00000343882, OTTHUMT00000041722
    Conserved Domains (1) summary
    cd00059
    Location:157237
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    108559823..108684769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266867.3XP_005266924.1  

    Conserved Domains (1) summary
    cl00061
    Location:1750
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. XM_011535626.1XP_011533928.1  

    Conserved Domains (1) summary
    cl00061
    Location:4072
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. XM_011535627.1XP_011533929.1  

    Conserved Domains (1) summary
    cl00061
    Location:2355
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  4. XM_011535628.1XP_011533930.1  

    See identical proteins and their annotated locations for XP_011533930.1

    UniProtKB/Swiss-Prot
    O43524
  5. XM_011535629.1XP_011533931.1  

    See identical proteins and their annotated locations for XP_011533931.1

    UniProtKB/Swiss-Prot
    O43524
  6. XM_005266868.2XP_005266925.1  

    See identical proteins and their annotated locations for XP_005266925.1

    UniProtKB/Swiss-Prot
    O43524
    Related
    ENSP00000446316, ENST00000540898

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    109143966..109268930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)