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    FOXO3 forkhead box O3 [ Homo sapiens ]

    Gene ID: 2309, updated on 20-May-2012
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    Summary

    Official Symbol
    FOXO3provided by HGNC
    Official Full Name
    forkhead box O3provided by HGNC
    Primary source
    HGNC:3821
    See related
    Ensembl:ENSG00000118689; HPRD:04061; MIM:602681; Vega:OTTHUMG00000015327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; MGC12739; MGC31925; DKFZp781A0677
    Summary
    This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6q21
    Sequence :
    Chromosome: 6; NC_000006.11 (108881026..109005971)
    See FOXO3 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36a pseudogene 24 Neighboring gene lactation elevated 1 Neighboring gene translocase of outer mitochondrial membrane 5 homolog (yeast) pseudogene Neighboring gene SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) pseudogene 8 Neighboring gene long intergenic non-protein coding RNA 222 Neighboring gene zinc finger protein 259 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. Yu C, et al. Carcinogenesis, 2012 Mar. PMID 22223847.
    2. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. Ho KK, et al. J Biol Chem, 2012 Jan 6. PMID 22128155.
    3. The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival. Obrador-Hevia A, et al. Br J Haematol, 2012 Feb. PMID 22107151.
    4. Association analysis of common variants in FOXO3 with type 2 diabetes in a South Indian Dravidian population. Nair AK, et al. Gene, 2012 Jan 10. PMID 22015955.
    5. NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II. Diebold I, et al. Mol Biol Cell, 2011 Nov. PMID 21965295.

    See all (215) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. study identified urotensin-II and NOX4 as new activators of FoxO3a, and MMP2 as a novel target gene of FoxO3a, and showed that activation of FoxO3a by this pathway promotes vascular growth.
      Title: NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.
    2. overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity.
      Title: The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.
    3. Nuclear translocation of FOXO3a can be regulated by ultraviolet irradiation through the c-Jun N-terminal protein kinase (JNK)-ERK kinase/Akt pathway.
      Title: A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation.
    4. These results suggest that 18beta-glycyrrhetinic acid induces apoptosis in human breast carcinoma MCF-7 cells via caspase activation and modulation of Akt/FOXO3a/Bim pathway.
      Title: 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.
    5. p38 phosphorylation of FOXO3a on Ser-7 is essential for its nuclear relocalization in response to doxorubicin.
      Title: Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin.
    6. FOXO3 was constitutively inactivated in mantle cell lymphoma cell lines. FOXO3-defective cells were resistant to PI3K/AKT inhibitors. FOXO3 is a relevant regulator of proliferation and apoptosis in MCL.
      Title: The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival.
    7. Findings suggest that FoxO3a may play a pivotal role in the control of differentiation and tumorigenicity of glioblastoma cancer stem-like cells.
      Title: FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity.
    8. Polymorphisms in the FOXO3 gene that are associated with longevity are not major risk factors for prostate cancer risk, in this population of Caucasian men
      Title: Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer.
    9. Studies indicate that FoxO1, 3 and 4 genes were discovered at the chromosomal breakpoints found in cancers and were initially implicated in cancer.
      Title: FoxO family members in cancer.
    10. FoxO3A is recruited to the promoters of nuclear-encoded mitochondrial genes where it directly antagonizes c-Myc function via a mechanism that does not require binding to the consensus FoxO recognition element.
      Title: FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function.
    Submit: New GeneRIF Correction See all (175)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.

    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
    vpr HIV-1 Vpr inhibits insulin- and Akt-induced cytoplasmic translocation of Foxo3a, a subtype of the forkhead transcription factors PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001446.1 NT_007592.14 CDKN1A    BIND  PubMed FoxO3 binds the distal region of the p21Cip1 promoter. 
    NP_001446.1 NC_000012.9 CDKN1B    BIND  PubMed FOXO3a interacts with p27Kip1 promoter. 
    NP_001446.1 NP_001269.2 CHUK    BIND  PubMed IKK-alpha interacts with and phosphorylates FOXO3a. This interaction was modelled on a demonstrated interaction between IKK-alpha from an unknown species and FOXO3a from human. 
    NP_001446.1 NP_005240.3 FOXG1    BIND  PubMed FoxO3 interacts with FoxG1. 
    NP_001446.1 NP_001547.1 IKBKB    BIND  PubMed IKK-beta interacts with and phosphorylates FOXO3a. 
    NP_001446.1 NP_036370.2 SIRT1    BIND  PubMed FOXO3 interacts with SIRT1. 
    NP_001446.1 NP_005893.1 SMAD3    BIND  PubMed FoxO3 interacts with Smad3. 
    NP_001446.1 NP_005350.1 SMAD4    BIND  PubMed FoxO3 interacts with Smad4. 
    NP_963853.1 NC_000002.9 BCL2L11    BIND  PubMed FoxO3a interacts with the BCL2L11 (Bim) promoter. 
    O43524 P31749 AKT1    HPRD  PubMed  
    O43524 O15111 CHUK    HPRD  PubMed  
    O43524 Q09472 EP300    HPRD  PubMed  
    O43524 P03372 ESR1    HPRD  PubMed  
    O43524 P55315 FOXG1    HPRD  PubMed  
    O43524 O14920 IKBKB    HPRD  PubMed  
    O43524 P55055 NR1H2    HPRD  PubMed  
    O43524 Q13133 NR1H3    HPRD  PubMed  
    O43524 O00141 SGK1    HPRD  PubMed  
    O43524 Q96EB6 SIRT1    HPRD  PubMed  
    O43524 Q15796 SMAD2    HPRD  PubMed  
    O43524 P84022 SMAD3    HPRD  PubMed  
    O43524 Q13485 SMAD4    HPRD  PubMed  
    O43524 P61981 YWHAG    HPRD  PubMed  
    O43524 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:108598 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108598 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:121948 C12orf44    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western 
    NP_001895.1 CTNNB1    BIND  PubMed beta-catenin interacts with FOXO3a. 
    BioGRID:108598 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:108474 FANCD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:108578 FKBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:108598 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:119685 NLK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:113222 NR1H2    BioGRID  PubMed Two-hybrid 
    BioGRID:108598 BioGRID:115373 NR1H3    BioGRID  PubMed Two-hybrid 
    BioGRID:108598 BioGRID:111251 PGK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:111821 RAD17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:116982 SIRT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:108598 BioGRID:110261 SMAD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:112665 STK4    BioGRID  PubMed Affinity Capture-Western 
    NP_000537.2 TP53    BIND  PubMed Foxo3a interacts with p53. 
    BioGRID:108598 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108598 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108598 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108598 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:113363 YWHAE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108598 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • AKT phosphorylates targets in the nucleus, organism-specific biosystem (from REACTOME)
      AKT phosphorylates targets in the nucleus, organism-specific biosystemAfter translocation into the nucleus, AKT can phosphorylate a number of targets there such as CREB, forkhead transcription factors, SRK and NUR77.
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
      Downstream signaling of activated FGFR, organism-specific biosystemSignaling via FGFRs is mediated via direct recruitment of signaling proteins that bind to tyrosine auto-phosphorylation sites on the activated receptor and via closely linked docking proteins that be...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Energy Metabolism, organism-specific biosystem (from WikiPathways)
      Energy Metabolism, organism-specific biosystemThe PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of ...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • IL2 signaling events mediated by PI3K, organism-specific biosystem (from Pathway Interaction Database)
      IL2 signaling events mediated by PI3K, organism-specific biosystem
      IL2 signaling events mediated by PI3K
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
      Insulin Pathway, organism-specific biosystem
      Insulin Pathway
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • PI-3K cascade, organism-specific biosystem (from REACTOME)
      PI-3K cascade, organism-specific biosystemThe ability of growth factors to protect from apoptosis is primarily due to the activation of the AKT survival pathway. P-I-3-kinase dependent activation of PDK leads to the activation of AKT which i...
    • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB2 signaling, organism-specific biosystemERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated t...
    • PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
      PI3K events in ERBB4 signaling, organism-specific biosystemThe CYT1 isoforms of ERBB4 possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K - PIK3R1 (Kaushansky et al. 2008, Cohen e...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of activation of receptor tyrosine kinases (RTKs). Following ligand binding and autophosphorylation, RTKs recruit the 85 kDa regulatory subunit of PI3K (PI...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by NODAL, organism-specific biosystem (from REACTOME)
      Signaling by NODAL, organism-specific biosystemSignaling by NODAL is essential for patterning of the axes of the embryo and formation of mesoderm and endoderm (reviewed in Schier 2009, Shen 2007). The NODAL proprotein is secreted and cleaved extr...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
      Trk receptor signaling mediated by PI3K and PLC-gamma
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    DNA binding, bending IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific distal enhancer binding RNA polymerase II transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
    		  
    antral ovarian follicle growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    induction of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    initiation of primordial ovarian follicle growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    oocyte maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    ovulation from ovarian follicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of sequence-specific DNA binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    regulation of translation IDA
    Inferred from Direct Assay
    more info
    		  
    response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    response to stress IDA
    Inferred from Direct Assay
    more info
    		  
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
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    General protein information

    Preferred Names
    forkhead box protein O3
    Names
    forkhead box protein O3
    forkhead box O3A
    forkhead in rhabdomyosarcoma-like 1
    forkhead homolog (rhabdomyosarcoma) like 1
    forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001455.3 → NP_001446.1  forkhead box protein O3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' end and represents the longer transcript compared to variant 2. Both variants encode the same protein.
      Source sequence(s)
      AF032886, AK024103, AL096818, AL365509, CA389775
      Consensus CDS
      CCDS5068.1
      UniProtKB/Swiss-Prot
      O43524
      Related
      ENSP00000385824, ENST00000406360
      Conserved Domains (1) summary
      cd00059
      Location:157 – 237
      Blast Score: 295
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    2. NM_201559.2 → NP_963853.1  forkhead box protein O3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK024103, AL096818, AL365509, BC020227, CD101760
      Consensus CDS
      CCDS5068.1
      UniProtKB/Swiss-Prot
      O43524
      Related
      ENSP00000339527, OTTHUMP00000016944, ENST00000343882, OTTHUMT00000041722
      Conserved Domains (1) summary
      cd00059
      Location:157 – 237
      Blast Score: 295
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      108881026..109005971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      106448666..106573173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AJ001590.1 CAA04861.1
    genomic AL096818.9 (13177..14208) None
    genomic AL365509.8 CAI16295.1
    genomic AL391646.12 CAI16405.1
    genomic CH471051.2 EAW48373.1
      EAW48374.1
    mRNA AB072905.1 None
    mRNA AF032886.1 AAC39592.1
    mRNA AI554317.1 None
    mRNA AJ001589.1 CAA04860.1
    mRNA AK024103.1 None
    mRNA AK092357.1 None
    mRNA AK122861.1 None
    mRNA AK301304.1 BAG62858.1
    mRNA AK303933.1 BAG64861.1
    mRNA BC020227.1 AAH20227.1
    mRNA BC021224.2 AAH21224.1
    mRNA BC045800.1 None
    mRNA BC068552.1 AAH68552.1
    mRNA CA389775.1 None
    mRNA CD101760.1 None
    mRNA CR749261.1 CAH18117.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43524.1 GenPept UniProtKB/Swiss-Prot:O43524
    Q68DV3 GenPept UniProtKB/TrEMBL:Q68DV3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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