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Ece1 endothelin converting enzyme 1 [ Mus musculus (house mouse) ]

Gene ID: 230857, updated on 28-May-2016
Official Symbol
Ece1provided by MGI
Official Full Name
endothelin converting enzyme 1provided by MGI
Primary source
MGI:MGI:1101357
See related
Ensembl:ENSMUSG00000057530 Vega:OTTMUSG00000009809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ECE-1; ECE-1a; ECE-1b; ECE-1d; AW322500
Orthologs
Location:
4; 4 D3
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (137862216..137965229)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (137418152..137521144)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, liver/bone/kidney Neighboring gene predicted gene, 32079 Neighboring gene uncharacterized LOC102634683 Neighboring gene predicted gene, 32394 Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene RIKEN cDNA 1700095J12 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
calcitonin catabolic process ISO
Inferred from Sequence Orthology
more info
 
ear development ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelin maturation ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
pharyngeal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
substance P catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Weibel-Palade body ISO
Inferred from Sequence Orthology
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
endothelin-converting enzyme 1
Names
endothelin-converting enzyme-1a
endothelin-converting enzyme-1b
endothelin-converting enzyme-1d
NP_955011.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199307.2NP_955011.1  endothelin-converting enzyme 1

    See identical proteins and their annotated locations for NP_955011.1

    Status: VALIDATED

    Source sequence(s)
    AK134088, BC060648, BG083532, BQ749244
    Consensus CDS
    CCDS18822.1
    UniProtKB/Swiss-Prot
    Q4PZA2
    Related
    ENSMUSP00000099576, OTTMUSP00000010377, ENSMUST00000102518, OTTMUST00000022738
    Conserved Domains (2) summary
    cd08662
    Location:102751
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:89744
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    137862216..137965229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538767.2XP_006538830.1  

    See identical proteins and their annotated locations for XP_006538830.1

    UniProtKB/Swiss-Prot
    Q4PZA2
    Conserved Domains (2) summary
    cd08662
    Location:102751
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:89744
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. XM_006538765.1XP_006538828.1  

    See identical proteins and their annotated locations for XP_006538828.1

    UniProtKB/Swiss-Prot
    Q4PZA2
    Conserved Domains (2) summary
    cd08662
    Location:118767
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:105760
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    136126032..136196612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)