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    MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase [ Homo sapiens ]

    Gene ID: 23077, updated on 11-May-2012
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    Summary

    Official Symbol
    MYCBP2provided by HGNC
    Official Full Name
    MYC binding protein 2, E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:23386
    Locus tag
    AC001226.5
    See related
    Ensembl:ENSG00000005810; HPRD:10104; MIM:610392; Vega:OTTHUMG00000017105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAM; FLJ10106; FLJ13826; FLJ21597; FLJ21646; KIAA0916; DKFZp686M08244
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    Genomic context

    Location :
    13q22
    Sequence :
    Chromosome: 13; NC_000013.10 (77618792..77901177, complement)
    See MYCBP2 in Epigenomics, MapViewer

    Chromosome 13 - NC_000013.10Genomic Context describing neighboring genes Neighboring gene ceroid-lipofuscinosis, neuronal 5 Neighboring gene F-box and leucine-rich repeat protein 3 Neighboring gene sciellin Neighboring gene UPF0607 protein ENSP00000383144-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Yin L, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534529.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    2. PAM protein activated by facilitating the GDP/GTP-exchange of RHEBL1 protein which is an activator of mTOR protein.
      Title: Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.
    3. Pam, through its interaction with tuberin, could regulate the ubiquitination and proteasomal degradation of the tuberin-hamartin complex particularly in the CNS
      Title: Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.
    4. Identifies the region in PAM that inhibits the domain of type V adenylyl cyclase.
      Title: Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity.
    5. PAM the longest lasting nontranscriptional regulator of adenylyl cyclase activity known to date and presents a novel mechanism for the temporal regulation of cAMP signaling
      Title: PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAC39928.1 NP_002458.1 MYC    BIND  PubMed Myc interacts with Pam. 
    O75592 P01106 MYC    HPRD  PubMed  
    O75592 Q05209 PTPN12    HPRD  PubMed  
    O75592 P61981 YWHAG    HPRD  PubMed  
    BioGRID:116709 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:107252 CALM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:116709 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:116709 BioGRID:114941 NR1D1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:116709 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:121649 WDR48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:116709 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    branchiomotor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell morphogenesis involved in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    central nervous system projection neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase MYCBP2
    Names
    probable E3 ubiquitin-protein ligase MYCBP2
    myc-binding protein 2
    pam/highwire/rpm-1 protein
    protein associated with Myc
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015057.4 → NP_055872.4  probable E3 ubiquitin-protein ligase MYCBP2

      Status: VALIDATED

      Source sequence(s)
      AC001226, AF075587, AL159154, AL159158, AL359257
      UniProtKB/Swiss-Prot
      O75592
      Related
      ENSP00000384288, ENST00000407578
      Conserved Domains (8) summary
      COG5184
      Location:527 – 716
      Blast Score: 135
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]
      cl02148
      Location:3748 – 3840
      Blast Score: 95
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination.
      pfam08005
      Location:1235 – 1386
      Blast Score: 538
      PHR; PHR domain
      smart00557
      Location:2394 – 2445
      Blast Score: 97
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00415
      Location:958 – 1006
      Blast Score: 167
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:683 – 712
      Blast Score: 112
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
      pfam13923
      Location:4425 – 4479
      Blast Score: 93
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
      cl15348
      Location:4426 – 4479
      Blast Score: 112
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000013.10 Reference GRCh37.p5 Primary Assembly

      Range
      77618792..77901177, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000145.1 Alternate HuRef

      Range
      58316505..58599005, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC001226.1 (76065..106987) None
    genomic AL159154.16 CAH73736.1
    genomic AL159158.12 CAI16842.1
    genomic AL359257.9 CAI39758.1
      CAI39759.1
    genomic CH471093.1 EAW80564.1
      EAW80565.1
      EAW80566.1
      EAW80567.1
    mRNA AA236471.1 None
    mRNA AB020723.1 BAA74939.1
    mRNA AF075587.1 AAC39928.1
    mRNA AF083244.1 AAD39842.1
    mRNA AK000968.1 BAA91448.1
    mRNA AK023888.1 None
    mRNA AK025250.1 None
    mRNA AK025299.1 None
    mRNA AK092651.1 None
    mRNA AL110277.1 CAB53712.1
    mRNA BC037971.2 AAH37971.1
    mRNA BE886946.1 None
    mRNA BI859936.1 None
    mRNA BX473679.1 None
    mRNA BX647202.1 None
    mRNA CN395460.1 None
    mRNA CN395461.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75592.3 GenPept UniProtKB/Swiss-Prot:O75592
    Q9NWD4 GenPept UniProtKB/TrEMBL:Q9NWD4
    Q9UG08 GenPept UniProtKB/TrEMBL:Q9UG08
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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