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Lrrc41 leucine rich repeat containing 41 [ Mus musculus (house mouse) ]

Gene ID: 230654, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc41provided by MGI
Official Full Name
leucine rich repeat containing 41provided by MGI
Primary source
MGI:MGI:2441984
See related
Ensembl:ENSMUSG00000028703 AllianceGenome:MGI:2441984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MUF1; D630045E04Rik; D730026A16Rik
Summary
Enables identical protein binding activity. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human LRRC41 (leucine rich repeat containing 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 72.1), testis adult (RPKM 51.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 53.1 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115932466..115954306)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116075269..116097109)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene NOL1/NOP2/Sun domain family, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene predicted gene, 52704 Neighboring gene RAD54 like (S. cerevisiae) Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582
  2. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. Kamura T, et al. J Biol Chem, 2001 Aug 10. PMID 11384984
  3. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Kamura T, et al. Genes Dev, 2004 Dec 15. PMID 15601820, Free PMC Article
  4. Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. He Y, et al. Aging Cell, 2021 Jul. PMID 34174788, Free PMC Article
  5. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
    Title: MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38941

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat-containing protein 41
Names
protein Muf1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153521.2 → NP_705741.3  leucine-rich repeat-containing protein 41

    See identical proteins and their annotated locations for NP_705741.3

    Status: VALIDATED

    Source sequence(s)
    AK052762, BB619031, BQ032399, BY033356
    Consensus CDS
    CCDS84786.1
    UniProtKB/Swiss-Prot
    A2A911, Q3U3S2, Q6IQY7, Q8K1C9, Q91VX4
    Related
    ENSMUSP00000030471.9, ENSMUST00000030471.9
    Conserved Domains (2) summary
    cd00116
    Location:598 → 744
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam06365
    Location:581 → 658
    CD34_antigen; CD34/Podocalyxin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115932466..115954306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253441.2 → XP_030109301.1  leucine-rich repeat-containing protein 41 isoform X1

  2. XM_030253442.1 → XP_030109302.1  leucine-rich repeat-containing protein 41 isoform X2

  3. XM_036164035.1 → XP_036019928.1  leucine-rich repeat-containing protein 41 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1C9.3 GenPept UniProtKB/Swiss-Prot:Q8K1C9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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