FOXM1 forkhead box M1 [Homo sapiens] - Gene

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Summary

Official Symbol: FOXM1provided by HGNC
Official Full Name: forkhead box M1provided by HGNC
Primary source: HGNC:3818
See related: Ensembl:ENSG00000111206; HPRD:03823; MIM:602341; Vega:OTTHUMG00000168118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MPP2; TGT3; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1B; HFH-11; TRIDENT; MPHOSPH2
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

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Genomic context

Location :: 12p13

Sequence :: Chromosome: 12; NC_000012.11 (2966849..2986303, complement)

See FOXM1 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In vivo suppression of the oncogenic FOXM1 after treatment with proteasome inhibitors.
Title: Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts.
FOXM1 induces epigenetic changes in normal human cells that resembles those found in the cancer methylome.
Title: FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
involvement of FOXM1 in various aspects of cancer, in particular its role and regulation within the context of cancer initiation, progression, and cancer drug response (Review)
Title: FOXM1: From cancer initiation to progression and treatment.
reveal a novel role for the MuvB complex in recruiting B-Myb and FoxM1 to promote late cell cycle gene expression and in regulating cell cycle gene expression from quiescence through mitosis.
Title: The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.
Findings defined Cav-1 as an important downstream oncogenic target of FoxM1, suggesting that dysregulated signaling of this novel FoxM1-Cav-1 pathway promotes pancreatic cancer development and progression.
Title: A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis.
FoxM1 knockdown sensitized the human cancer cells to apoptotic cell death induced by proteasome inhibitors
Title: FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy.
FoxM1 and its associated signaling pathway play a critical role in the pathogenesis of papillary thyroid carcinoma and may be a potential target for therapeutic intervention for treatment of these cancers.
Title: FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma.
Data show that the expressions of phospho-ERK and FOXM1 had significantly positive correlation.
Title: Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells.
FoxM1 mutations that disrupt the FoxM1-beta-catenin interaction or FoxM1 nuclear import prevent beta-catenin nuclear accumulation in tumor cells.
Title: FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.
in cancer cells NPM interacts with FOXM1 and their interaction is required for sustaining the level and localization of FOXM1.
Title: Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.

Submit: New GeneRIF Correction See all (86)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q08050	P06493	CDK1	HPRD	PubMed
Q08050	P24941	CDK2	HPRD	PubMed
Q08050	Q92793	CREBBP	HPRD	PubMed
Q08050	P40763	STAT3	HPRD	PubMed
	NC_000005.8	CCNB1	BIND	PubMed	FoxM1 interacts with the Cyclin B1 promoter.
BioGRID:108594	BioGRID:107332	CCNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:107338	CCNE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:107429	CDC25B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:108594	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western
	NC_000001.8	CENPF	BIND	PubMed	FoxM1 interacts with the CENP-F promoter.
BioGRID:108594	BioGRID:116369	CHEK2	BioGRID	PubMed	Biochemical Activity
BioGRID:108594	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108594	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108594	BioGRID:122933	ZBTB3	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	TAS Traceable Author Statement more info	PubMed
DNA binding, bending	IBA Inferred from Biological aspect of Ancestor more info
double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IBA Inferred from Biological aspect of Ancestor more info
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
DNA repair	IEA Inferred from Electronic Annotation more info
G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
cell cycle	IEA Inferred from Electronic Annotation more info
cell cycle	TAS Traceable Author Statement more info	PubMed
embryo development	IBA Inferred from Biological aspect of Ancestor more info
liver development	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of cell aging	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell growth	TAS Traceable Author Statement more info	PubMed
regulation of cell proliferation	NAS Non-traceable Author Statement more info	PubMed
regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of sequence-specific DNA binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
tissue development	IBA Inferred from Biological aspect of Ancestor more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
vasculogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Preferred Names: forkhead box protein M1

Names: forkhead box protein M1; M-phase phosphoprotein 2; HNF-3/fork-head homolog 11; transcription factor Trident; MPM-2 reactive phosphoprotein 2; forkhead-related protein FKHL16; winged-helix factor from INS-1 cells; Forkhead, drosophila, homolog-like 16; hepatocyte nuclear factor 3 forkhead homolog 11

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029590.1 RefSeqGene

Range

5001..24475

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243088.1 → NP_001230017.1 forkhead box protein M1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK313845, AW780338, DB137846, U74612

UniProtKB/Swiss-Prot

Q08050

Conserved Domains (1) summary

cd00059
Location:235 – 310
Blast Score: 309

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001243089.1 → NP_001230018.1 forkhead box protein M1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK291206, AW780338, DB137846, U83113

UniProtKB/TrEMBL

A8K591

UniProtKB/Swiss-Prot

Q08050

Conserved Domains (1) summary

cd00059
Location:235 – 310
Blast Score: 309

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_021953.3 → NP_068772.2 forkhead box protein M1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AW780338, DB137846, U83113

Consensus CDS

CCDS8515.1

UniProtKB/Swiss-Prot

Q08050

UniProtKB/TrEMBL

Q53Y49

Related

ENSP00000352901, OTTHUMP00000237985, ENST00000359843, OTTHUMT00000398272

Conserved Domains (1) summary

cd00059
Location:236 – 311
Blast Score: 309

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_202002.2 → NP_973731.1 forkhead box protein M1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AW780338, DB137846, U74612

Consensus CDS

CCDS8516.1

UniProtKB/Swiss-Prot

Q08050

Related

ENSP00000342307, OTTHUMP00000237983, ENST00000342628, OTTHUMT00000398270

Conserved Domains (1) summary

cd00059
Location:236 – 311
Blast Score: 310

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_202003.2 → NP_973732.1 forkhead box protein M1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AW780338, DB137846, U74613

Consensus CDS

CCDS8517.1

UniProtKB/Swiss-Prot

Q08050

Related

ENSP00000354492, OTTHUMP00000237984, ENST00000361953, OTTHUMT00000398271

Conserved Domains (1) summary

cd00059
Location:236 – 311
Blast Score: 309

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

2966849..2986303, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

2824364..2843534, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005841.3	None
genomic	AC005911.6 (99353..100485)	None
genomic	CH471116.2	EAW88880.1
		EAW88881.1
		EAW88882.1
		EAW88883.1
genomic	CS174342.1	CAJ34550.1
genomic	DQ022289.1	AAY26401.1
genomic	FB292650.1	CAP58600.1
genomic	JA417749.1	CCD32724.1
mRNA	AK291206.1	BAF83895.1
mRNA	AK313845.1	None
mRNA	AW780338.1	None
mRNA	AY542306.1	AAT08175.1
mRNA	BC006192.2	AAH06192.1
mRNA	BC006529.2	AAH06529.1
mRNA	BC012863.1	AAH12863.1
mRNA	BC035437.1	None
mRNA	BQ229497.1	None
mRNA	BT006986.1	AAP35632.1
mRNA	DB137846.1	None
mRNA	L16783.1	AAC37541.1
mRNA	U74612.1	AAC51128.1
mRNA	U74613.1	AAC51129.1
mRNA	U83113.1	AAC63595.1
other-genetic	JF432495.1	ADZ15712.1